Results 101 to 110 of about 113,437 (249)

How Can Pharmacology Help Us Overcome the Challenges of Drug Repositioning as Antivirals to Treat Emerging Pathogens? The Example of Covid‐19

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
Pharmacological pitfalls and challenges in drug repurposing for emerging pathogens: lessons from COVID‐19. ABSTRACT The Covid‐19 pandemic highlighted the urgent need for effective therapies against emerging pathogens. Drug repurposing, defined as the use of existing medications for new therapeutic purposes, was extensively pursued for SARS‐CoV‐2 but ...
Inès Ben Ghezala, Nathan Peiffer‐Smadja, Caroline Solas, Antoine Nougairède, Franck Touret, Marc Bardou   +5 more
wiley   +1 more source

Body condition score and weight are effective targeted selective treatment indicators for gastrointestinal nematodes in premating ewes

Veterinary Record, Volume 198, Issue 3, Page e85-e91, 31 January/7 February 2026.
Abstract Background Ewe reproductive performance is key for flock profitability but can be impacted upon by gastrointestinal nematode (GIN) infections. Farmers commonly deworm ewes pre‐mating, yet concerns regarding anthelmintic resistance increase pressure to reduce wormer use.
Eiry G. Williams, Peter M. Brophy, Hefin W. Williams, Serian R. Evans, Heather McCalman, Rhys A. Jones   +5 more
wiley   +1 more source

Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Macrocyclic lactone (ML) anthelmintics are the most important class of anthelmintics because of our high dependence on them for the control of nematode parasites and some ectoparasites in livestock, companion animals and in humans. However, resistance to
Roger K. Prichard, Timothy G. Geary
doaj   +1 more source

Total synthesis of the antimitotic marine macrolide (-)-leiodermatolide. [PDF]

, 2014
Leiodermatolide is an antimitotic macrolide isolated from the marine sponge Leiodermatium sp. whose potentially novel tubulin-targeting mechanism of action makes it an exciting lead for anticancer drug discovery.
Altmann, Baker, Comins, Cowden, Cragg, Cragg, Cragg, Crossman, Dalby, Dalby, Evans, Evans, Fürstner, Gray, Inanaga, Jeffery, Kan, Kavallaris, Kočovský, Mukaiyama, Navickas, Nicolaou, Paterson, Paterson, Paterson, Paterson, Paterson, Paterson, Paterson, Paterson, Paterson, Paterson, Paterson, Paterson, Paterson, Paterson, Paterson, Raspoet, Rink, Shibahara, Smith, Stille, Stork, Taniguchi, Verma, Verma, White, Willwacher, Zhong   +48 more
core   +2 more sources

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Structural diversity and biological activities of naturally derived bafilomycins from actinomycetes

Beni-Suef University Journal of Basic and Applied Sciences
Background Bafilomycins (Baf) are plecomacrolide antibiotics characterized by a 16-membered macrocyclic lactone containing two sets of conjugated dienes linked by a 1,3-dimethyl propan-2-ol (C3) spacer to an unusually folded tetrahydropyran ring.
Aileen Bayot Custodio, John Edward Ico Zapater, Edwin Plata Alcantara   +2 more
doaj   +1 more source

Efficacy of oral moxidectin against susceptible and resistant isolates of Dirofilaria immitis in dogs

Parasites & Vectors, 2017
Background Monthly topical and sustained-release injectable formulations of moxidectin are currently marketed; however, an oral formulation, while approved at a dose of 3 μg/kg, is not currently marketed in the United States.
Tom L. McTier, Robert H. Six, Aleah Pullins, Sara Chapin, John W. McCall, Douglas Rugg, Steven J. Maeder, Debra J. Woods   +7 more
doaj   +1 more source

Zearalenone Mycotoxicosis: Pathophysiology and Immunotoxicity

The Iraqi Journal of Veterinary Medicine, 2020
Mycotoxicosis refers to the deleterious pathological effects of different types of toxins produced by some worldwide distributing fungi. Mycotoxins, as secondary metabolites are affecting different organs and systems both in animals and human beings ...
Ajwad A. M. Assumaidaee, Nathera M. Ali, Shahad W. Ahmed   +2 more
doaj   +1 more source

Milk quality parameters associated with the occurrence of veterinary drug residues in bulk tank milk

Scientia Agricola
Veterinary drug residues in bulk tank milk are important to all sectors of the dairy chain because they are one of the major factors which determine the safety of the final product.
Lidia Cristina Almeida Picinin, Isabela Maia Toaldo, Rodrigo Barcellos Hoff, Fernando Nogueira Souza, Mônica Oliveira Leite, Leorges Moraes Fonseca, Soraia Araújo Diniz, Marcos Xavier Silva, João Paulo Amaral Haddad, Mônica Maria Oliveira Pinho Cerqueira, Marilde Terezinha Bordignon-Luiz   +10 more
doaj   +1 more source

First report of multiple anthelmintic resistance in goat farm in Cuba [PDF]

, 2017
This study determined the efficacies of four classes of anthelmintics (AH) in a goat flock where anthelmintic resistance (AR) to ivermectin was suspected. We selected and randomly distributed 105 animals with >500 eggs per gram of feces into seven groups
Arece García, Javier, Arece García, Javier, GONZALEZ GARDUÑO, ROBERTO, GONZALEZ GARDUÑO, ROBERTO, López Arellano, María Eugenia, López Arellano, María Eugenia, López Leyva, Yoel, López Leyva, Yoel, Mendoza de Gives, Pedro, Mendoza de Gives, Pedro, OLMEDO JUAREZ, AGUSTIN, OLMEDO JUAREZ, AGUSTIN, RAMIREZ VARGAS, GABRIEL, RAMIREZ VARGAS, GABRIEL, REYES GUERRERO, DAVID EMANUEL, REYES GUERRERO, DAVID EMANUEL, ROJO RUBIO, ROLANDO, ROJO RUBIO, ROLANDO, Varady, Michal, Varady, Michal   +19 more
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