Results 111 to 120 of about 8,305 (169)
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Macrocyclic lactone resistance in Dirofilaria immitis
Veterinary Parasitology, 2011Microfilariae were isolated from a Katrina rescue dog that remained microfilariaemic despite successful adulticidal treatments and repeated treatment with high doses of macrocyclic lactones (MLs). The microfilariae were genotyped at two P-glycoprotein single nucleotide polymorphic sites which had been found to correlate with reduced sensitivity to MLs.
Roger K Prichard +2 more
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Resistance to Macrocyclic Lactones
Current Pharmaceutical Biotechnology, 2012Resistance to the macrocyclic lactones (MLs) has been confirmed or suspected in many target organisms and is a serious problem in some. For some species, such as parasitic nematodes of small ruminants, ML resistance has become severe enough to threaten effective worm control worm control.
Adrian J, Wolstenholme, Ray M, Kaplan
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Macrocyclic lactone resistance in cyathostomins
Veterinary Record, 2008SIR, — The beginning of resistance of cyatho stomins to the macrocyclic lac-tones has been suggested by the less than complete reduction in egg counts after treatment with ivermectin in Germany ([von Samson-Himmelstjerna and others 2007][1]), the occurrence of eggs in faeces 28 days ...
Dudeney, A, Campbell, C, Coles, GC
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Macrocyclic lactone endectocides
2012The macrocyclic lactone endectocides such as ivermectin, abamectin, selamectin and moxidectin have revolutionized the treatment of parasitic diseases in animals, being active against internal and external parasites. Ivermectin was introduced into veterinary medicine in the 1980s and since that time a number of related compounds have been introduced. In
Sharon M. Gwaltney-Brant +2 more
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Use of Macrocyclic Lactones in Cattle in the USA
Current Pharmaceutical Biotechnology, 2012The use of macrocyclic lactones has become the main stay for the treatment of endo- and ectoparasites in the cattle industry. Here we review those drugs that are currently approved for use in cattle in the United States. The general efficacy, tissue distribution and toxicity of each drug formulation are discussed. Included is a discussion regarding the
Lora R, Ballweber, Laurie A, Baeten
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Macrocyclic Lactones for Parasite Control in Equids
Current Pharmaceutical Biotechnology, 2012Macrocyclic lactones (MLs) revolutionized parasite control in horses and other animals. They are unique in that they are effective against arthropods and nematodes. The first of the widely used avermectins was ivermectin. In 1983, it was marketed for use in horses as an injectable formulation but was withdrawn in 1984 after about a year and half on the
E T, Lyons, S C, Tolliver
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Macrocyclic Lactones and Dirofilaria immitis Microfilariae
Topics in Companion Animal Medicine, 2011Although there has been extensive veterinary focus on both the effectiveness of macrocyclic lactones for heartworm prevention in dogs and their adulticidal effects, little attention has been directed to their effects on heartworm microfilariae. With routine use of macrocyclic lactones, in some cases knowingly, in dogs with existing heartworm infections,
Dwight D, Bowman, Claire, Mannella
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Pharmacokinetic Features of the Antiparasitic Macrocyclic Lactones
Current Pharmaceutical Biotechnology, 2012The macrocyclic lactones have pharmacokinetic properties which enhance their use against endo- and ectoparasites in animals and man. The most consistent physico-chemical feature of the group which contributes to their kinetic characteristics is high lipid solubility.
Quintin A, McKellar, Cengiz, Gokbulut
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Bulletin of the Academy of Sciences, USSR Division of Chemical Science, 1964
A sixteen-membered diacetylenic β-hydroxy lactone was synthesized by the oxidative intramolecular condensation of acetylenes, and by its reduction the corresponding dienic and saturated β-hydroxy lactones were prepared.
L. D. Bergel'son, Yul G. Molotkovskii
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A sixteen-membered diacetylenic β-hydroxy lactone was synthesized by the oxidative intramolecular condensation of acetylenes, and by its reduction the corresponding dienic and saturated β-hydroxy lactones were prepared.
L. D. Bergel'son, Yul G. Molotkovskii
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Acute Human Toxicity of Macrocyclic Lactones
Current Pharmaceutical Biotechnology, 2012Macrocyclic lactones, including avermectins and milbemycins, are novel parasiticides and insecticides that are produced through fermentation by soil-dwelling microorganisms. Although various macrocyclic lactones may differ in their potency and safety, all of them are believed to share common pharmacologic/toxicologic mechanisms, i.e.
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