Results 1 to 10 of about 2,294 (116)

Analyses of emerging macrocyclic lactone resistance: Speed and signature of ivermectin and moxidectin selection and evidence of a shared genetic locus. [PDF]

PLoS Pathogens
Subtherapeutic treatment or 'underdosing' is considered a common problem in the control of parasitic helminths of animals and people and can hasten the emergence of anthelmintic resistance.
Jennifer McIntyre, Alison Morrison, Kirsty Maitland, Eileen Devaney, James A Cotton, Collette Britton, Ray M Kaplan, Dave Bartley, Roz Laing   +8 more
doaj   +2 more sources

Identification of a moxidectin dose for 4- to 11-year-old children to support registration and potential use for onchocerciasis elimination: results of an open-label pharmacokinetic and safety study [PDF]

Parasites & Vectors
Background The WHO and onchocerciasis-endemic countries target elimination of the transmission of Onchocerca volvulus, the parasite causing onchocerciasis, primarily through ivermectin mass drug administration (MDA).
Nicholas O. Opoku, Felix Doe, Mannel E. Agbogah, Rukaya Laryea, Shelter K. Gordor, Bismark S. Donkor, Edwin Anyomitse, Dickson Kugali, Mariëlle van Zutphen-van Geffen, Danielle J. Navarro, Craig R. Rayner, Kashyap Patel, Annette C. Kuesel, Melinda Lowe, Sally Kinrade   +14 more
doaj   +2 more sources

A pilot study on the potency of injectable vs. oral moxidectin formulation to suppress strongyle egg excretion in horses at twice lower dose [PDF]

Helminthologia
The aim of present study was to examine the potency of moxidectin solution (Cydectin 1 %; Zoetis) and commercially available oral moxidectin gel (Equest®; Zoetis) to suppress the excretion of strongyle eggs in horses over a 6-week period.
Šarkūnas M., Schwahn A., Suleimanova K.   +2 more
doaj   +2 more sources

Pharmacokinetics of oral moxidectin in individuals with Onchocerca volvulus infection.

PLoS Neglected Tropical Diseases, 2022
BackgroundOnchocerciasis ("river blindness"), is a neglected tropical disease caused by the filarial nematode Onchocerca volvulus and transmitted to humans through repeated bites by infective blackflies of the genus Simulium.
Beesan Tan, Nicholas Opoku, Simon K Attah, Kwablah Awadzi, Annette C Kuesel, Janis Lazdins-Helds, Craig Rayner, Victoria Ryg-Cornejo, Mark Sullivan, Lawrence Fleckenstein   +9 more
doaj   +1 more source

Bugs and drugs: a systems biology approach to characterising the effect of moxidectin on the horse’s faecal microbiome

Animal Microbiome, 2020
Background Anthelmintic treatment is a risk factor for intestinal disease in the horse, known as colic. However the mechanisms involved in the onset of disease post anthelmintic treatment are unknown.
S. P. Daniels, J. Leng, J. R. Swann, C. J. Proudman   +3 more
doaj   +1 more source

Comparative efficacy of Moxidectin and Ivermectin in cattle naturally infected with old world screw worm larvae [PDF]

Iraqi Journal of Veterinary Sciences, 2005
Moxidectin is a second generation semi-synthetic Macrocyclic Lactone of the Milbemycins family, which have a broad spectrum of activity against external and internal parasite including Oestrus ovis and hypodermatosis.
E A Hassan, A Y Al-Karogholli, A S Hassan, M O Al-Ani   +3 more
doaj   +1 more source

Preventive efficacy of oral moxidectin at various doses and dosage regimens against macrocyclic lactone-resistant heartworm (Dirofilaria immitis) strains in dogs

Parasites & Vectors, 2019
Background Moxidectin has previously shown limited efficacy (≤ 44.4%) against confirmed macrocyclic lactone (ML)-resistant Dirofilaria immitis strains at 3 µg/kg after single and multiple oral dosages. Three studies were conducted to evaluate higher oral
Tom L. McTier, Robert H. Six, Aleah Pullins, Sara Chapin, Kristina Kryda, Sean P. Mahabir, Debra J. Woods, Steven J. Maeder   +7 more
doaj   +1 more source

Study of the pharmacokinetics of moxidectin in the body of carnivores using an antiparasitic drug in the form of tablets

Российский паразитологический журнал, 2021
The purpose of the research is studying the pharmacokinetics of moxidectin in the blood serum of cats and dogs after a single administration of antiparasitic drug «Neoterika Protecto tablets».Materials and methods.
G. B. Arisova
doaj   +1 more source

Temperature moderates impact of formulated moxidectin on seed germination of three temperate grassland species

PLoS ONE, 2022
Formulations of macrocyclic lactone anthelmintics such as moxidectin are regularly administered to sheep to combat parasites. A disadvantage of these pharmaceuticals are their side effects on non-target organisms when entering the environment.
Carsten Eichberg, Alwin M. Hartman, Alexandra-Marie Kronenberger, Rolf-Alexander Düring, Tobias W. Donath   +4 more
doaj   +3 more sources

Efficacy of orally administered combination of moxidectin, sarolaner and pyrantel (Simparica Trio™) for the prevention of experimental Angiostrongylus vasorum infection in dogs

Parasites & Vectors, 2020
Background Infection with Angiostrongylus vasorum may cause severe clinical disease, even death in dogs, however, due to the often non-specific clinical signs, diagnosis is not always straightforward. Regular prophylactic treatment may offer a safe means
Csilla Becskei, Mirjan Thys, Padraig Doherty, Sean P. Mahabir   +3 more
doaj   +1 more source