Pharmacokinetics of oral moxidectin in individuals with Onchocerca volvulus infection.
PLoS Neglected Tropical Diseases, 2022 BackgroundOnchocerciasis ("river blindness"), is a neglected tropical disease caused by the filarial nematode Onchocerca volvulus and transmitted to humans through repeated bites by infective blackflies of the genus Simulium.
Beesan Tan +9 more
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Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial. [PDF]
PLoS Neglected Tropical Diseases, 2016 BACKGROUND:Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or ...
Beatrice Barda +5 more
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Bugs and drugs: a systems biology approach to characterising the effect of moxidectin on the horse’s faecal microbiome [PDF]
Animal Microbiome, 2020 Background Anthelmintic treatment is a risk factor for intestinal disease in the horse, known as colic. However the mechanisms involved in the onset of disease post anthelmintic treatment are unknown.
S. P. Daniels +3 more
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Analyses of emerging macrocyclic lactone resistance: Speed and signature of ivermectin and moxidectin selection and evidence of a shared genetic locus. [PDF]
PLoS PathogensSubtherapeutic treatment or 'underdosing' is considered a common problem in the control of parasitic helminths of animals and people and can hasten the emergence of anthelmintic resistance.
Jennifer McIntyre +8 more
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Parasites & Vectors, 2017 Background Monthly topical and sustained-release injectable formulations of moxidectin are currently marketed; however, an oral formulation, while approved at a dose of 3 μg/kg, is not currently marketed in the United States.
Tom L. McTier +7 more
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Combined high-quality metagenomics reveals off-target effects of albendazole, ivermectin-albendazole and moxidectin-albendazole on the human gut bacteria [PDF]
npj Biofilms and MicrobiomesHuman whipworm infections caused by Trichuris trichiura and Trichuris incognita remain a major public health problem, affecting over 400 million people globally and responding poorly to standard benzimidazole chemotherapy.
Julian Dommann +7 more
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Comparative efficacy of Moxidectin and Ivermectin in cattle naturally infected with old world screw worm larvae [PDF]
Iraqi Journal of Veterinary Sciences, 2005 Moxidectin is a second generation semi-synthetic Macrocyclic Lactone of the Milbemycins family, which have a broad spectrum of activity against external and internal parasite including Oestrus ovis and hypodermatosis.
E A Hassan +3 more
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Российский паразитологический журнал, 2021 The purpose of the research is studying the pharmacokinetics of moxidectin in the blood serum of cats and dogs after a single administration of antiparasitic drug «Neoterika Protecto tablets».Materials and methods.
G. B. Arisova
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Parasites & Vectors, 2019 Background Moxidectin has previously shown limited efficacy (≤ 44.4%) against confirmed macrocyclic lactone (ML)-resistant Dirofilaria immitis strains at 3 µg/kg after single and multiple oral dosages. Three studies were conducted to evaluate higher oral
Tom L. McTier +7 more
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Parasites & Vectors, 2020 Background Infection with Angiostrongylus vasorum may cause severe clinical disease, even death in dogs, however, due to the often non-specific clinical signs, diagnosis is not always straightforward. Regular prophylactic treatment may offer a safe means
Csilla Becskei +3 more
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