Results 1 to 10 of about 2,380 (175)

Analyses of emerging macrocyclic lactone resistance: Speed and signature of ivermectin and moxidectin selection and evidence of a shared genetic locus. [PDF]

PLoS Pathogens
Subtherapeutic treatment or 'underdosing' is considered a common problem in the control of parasitic helminths of animals and people and can hasten the emergence of anthelmintic resistance.
Jennifer McIntyre, Alison Morrison, Kirsty Maitland, Eileen Devaney, James A Cotton, Collette Britton, Ray M Kaplan, Dave Bartley, Roz Laing   +8 more
doaj   +2 more sources

Trends in Veterinary Drug Residues in US Cattle: Analysing USDA Sampling Data. [PDF]

Vet Med Sci
National US residue monitoring data (2021–2023) were analysed to characterise veterinary drug residue detections in cattle. Detection patterns varied by cattle type, with dairy cows accounting for the highest number of detections and a consistent group of commonly used drugs responsible for most violative and non‐violative findings.
Alwahaimed AS, Eifert J.
europepmc   +2 more sources

Functional Characterization of the Cat and Dog Wild-Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany. [PDF]

J Vet Pharmacol Ther
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Siegl L, Bethäuser M, Nürnberger D, Oswald S, Moritz A, Hamann M, Geyer J.   +6 more
europepmc   +2 more sources

A pilot study on the potency of injectable vs. oral moxidectin formulation to suppress strongyle egg excretion in horses at twice lower dose [PDF]

Helminthologia
The aim of present study was to examine the potency of moxidectin solution (Cydectin 1 %; Zoetis) and commercially available oral moxidectin gel (Equest®; Zoetis) to suppress the excretion of strongyle eggs in horses over a 6-week period.
Šarkūnas M., Schwahn A., Suleimanova K.   +2 more
doaj   +2 more sources

Pharmacokinetics of oral moxidectin in individuals with Onchocerca volvulus infection.

PLoS Neglected Tropical Diseases, 2022
BackgroundOnchocerciasis ("river blindness"), is a neglected tropical disease caused by the filarial nematode Onchocerca volvulus and transmitted to humans through repeated bites by infective blackflies of the genus Simulium.
Beesan Tan, Nicholas Opoku, Simon K Attah, Kwablah Awadzi, Annette C Kuesel, Janis Lazdins-Helds, Craig Rayner, Victoria Ryg-Cornejo, Mark Sullivan, Lawrence Fleckenstein   +9 more
doaj   +1 more source

Bugs and drugs: a systems biology approach to characterising the effect of moxidectin on the horse’s faecal microbiome

Animal Microbiome, 2020
Background Anthelmintic treatment is a risk factor for intestinal disease in the horse, known as colic. However the mechanisms involved in the onset of disease post anthelmintic treatment are unknown.
S. P. Daniels, J. Leng, J. R. Swann, C. J. Proudman   +3 more
doaj   +1 more source

Comparative efficacy of Moxidectin and Ivermectin in cattle naturally infected with old world screw worm larvae [PDF]

Iraqi Journal of Veterinary Sciences, 2005
Moxidectin is a second generation semi-synthetic Macrocyclic Lactone of the Milbemycins family, which have a broad spectrum of activity against external and internal parasite including Oestrus ovis and hypodermatosis.
E A Hassan, A Y Al-Karogholli, A S Hassan, M O Al-Ani   +3 more
doaj   +1 more source

Study of the pharmacokinetics of moxidectin in the body of carnivores using an antiparasitic drug in the form of tablets

Российский паразитологический журнал, 2021
The purpose of the research is studying the pharmacokinetics of moxidectin in the blood serum of cats and dogs after a single administration of antiparasitic drug «Neoterika Protecto tablets».Materials and methods.
G. B. Arisova
doaj   +1 more source

Preventive efficacy of oral moxidectin at various doses and dosage regimens against macrocyclic lactone-resistant heartworm (Dirofilaria immitis) strains in dogs

Parasites & Vectors, 2019
Background Moxidectin has previously shown limited efficacy (≤ 44.4%) against confirmed macrocyclic lactone (ML)-resistant Dirofilaria immitis strains at 3 µg/kg after single and multiple oral dosages. Three studies were conducted to evaluate higher oral
Tom L. McTier, Robert H. Six, Aleah Pullins, Sara Chapin, Kristina Kryda, Sean P. Mahabir, Debra J. Woods, Steven J. Maeder   +7 more
doaj   +1 more source

Efficacy of orally administered combination of moxidectin, sarolaner and pyrantel (Simparica Trio™) for the prevention of experimental Angiostrongylus vasorum infection in dogs

Parasites & Vectors, 2020
Background Infection with Angiostrongylus vasorum may cause severe clinical disease, even death in dogs, however, due to the often non-specific clinical signs, diagnosis is not always straightforward. Regular prophylactic treatment may offer a safe means
Csilla Becskei, Mirjan Thys, Padraig Doherty, Sean P. Mahabir   +3 more
doaj   +1 more source