The macrocyclic lactone oxacyclododecindione reduces fibrosis progression [PDF]
Frontiers in Pharmacology, 2023 Background: Renal fibrosis is one of the most important triggers of chronic kidney disease (CKD), and only a very limited number of therapeutic options are available to stop fibrosis progression.
Sabrina Saurin +7 more
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Inherent P-glycoprotein deficiency and macrocyclic lactone toxicity in an Australian Maine Coon cat homozygous for 1930_1931del TC [PDF]
Journal of Feline Medicine and Surgery Open ReportsCase summary A 9-month-old castrated male Maine Coon cat developed tongue protrusion, mydriasis, generalised weakness and ataxia after routine application, as per label guidelines, of NexGard Spectra (Boehringer Ingelheim; active ingredients praziquantel
Madeleine L Roberts
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The first report of macrocyclic lactone resistant cyathostomins in the UK [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2023 In recent years, resistance to the benzimidazole (BZ) and tetrahydropyrimidine (PYR) anthelmintics in global cyathostomin populations, has led to reliance on the macrocyclic lactone drugs (ML-of which ivermectin and moxidectin are licensed in horses) to ...
K.E. Bull +3 more
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A diagnostic algorithm for evaluating cases of potential macrocyclic lactone–resistant heartworm [PDF]
Parasites & Vectors, 2017 Background The emergence of macrocyclic lactone resistance in canine heartworm poses a substantial threat to what is currently the only effective, FDA-approved available method of prevention.
Andrew R. Moorhead +2 more
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Moxidectin: heartworm disease prevention in dogs in the face of emerging macrocyclic lactone resistance [PDF]
Parasites & Vectors, 2022 Heartworm (Dirofilaria immitis) disease continues to increase and spread, remaining one of the most important and pathogenic parasitic diseases of dogs, despite the regular use of macrocyclic lactones (MLs) in preventive products.
Molly D. Savadelis +4 more
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Analyses of emerging macrocyclic lactone resistance: Speed and signature of ivermectin and moxidectin selection and evidence of a shared genetic locus. [PDF]
PLoS PathogensSubtherapeutic treatment or 'underdosing' is considered a common problem in the control of parasitic helminths of animals and people and can hasten the emergence of anthelmintic resistance.
Jennifer McIntyre +8 more
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Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2020 Anthelmintic resistance in equine cyathostomins is both widespread and highly prevalent in the benzimidazole and tetrahydropyrimidine classes; however, reports of resistance to macrocyclic lactone (ML) drugs are sparse and sporadic.
M.K. Nielsen, M. Banahan, R.M. Kaplan
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Laboratory assays reveal diverse phenotypes among microfilariae of Dirofilaria immitis isolates with known macrocyclic lactone susceptibility status. [PDF]
PLoS ONE, 2020 Prevention of canine heartworm disease caused by Dirofilaria immitis relies on chemoprophylaxis with macrocyclic lactone anthelmintics. Alarmingly, there are increased reports of D. immitis isolates with resistance to macrocyclic lactones and the ability
Jeba R J Jesudoss Chelladurai +5 more
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Shifting the paradigm in Dirofilaria immitis prevention: blocking transmission from mosquitoes to dogs using repellents/insecticides and macrocyclic lactone prevention as part of a multimodal approach [PDF]
Parasites & Vectors, 2017 Background This study assessed the influence of a topical ectoparasiticide (dinotefuran-permethrin-pyriproxyfen, DPP, Vectra® 3D, Ceva Animal Health) combined with a macrocyclic lactone (milbemycin oxime, MBO, Interceptor®, Virbac) on transmission of ...
John W. McCall +8 more
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Clinical validation of molecular markers of macrocyclic lactone resistance in Dirofilaria immitis [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2018 Prophylaxis with macrocyclic lactone (ML) endectocides is the primary strategy for heartworm control. Recent evidence has confirmed that ML-resistant Dirofilaria immitis isolates have evolved.
Cristina Ballesteros +5 more
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