Results 21 to 30 of about 442 (127)
Macrolactam analogues of macrolide natural products
Organic & Biomolecular Chemistry, 2016 The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity.
Hugel, Helmut M +2 more
openaire +4 more sources
Beilstein Journal of Organic Chemistry, 2019 A methodology for the solid-phase synthesis of biaryl bicyclic peptides containing a Phe-Phe, a Phe-Tyr or a Tyr-Tyr motif has been devised. This approach comprises two key steps.
Iteng Ng-Choi +3 more
doaj +1 more source
Nucleoside Recognition by a Fluorescent Macrolactam [PDF]
Bulletin of the Korean Chemical Society, 2007 Molecular recognition of nucleosides or nucleotides is attracting a great deal of interest due to their genetic functions in living organisms. Hydrophilic nature of nucleosides and nucleotides allows only a conformationally well defined receptor to form a hydrogen-bonded, electrostatic or hydrophobic complex with nucleosides or nucleotides in water ...
openaire +1 more source
Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides
Angewandte Chemie, Volume 137, Issue 20, May 12, 2025.The hypothesized convergent biosynthesis of triculamin‐like lasso peptides from different biosynthetic gene cluster (BGC) types represented across multiple bacterial phyla. The elucidation of the triculamin non‐canonical BGC and resistance mechanism by heterologous expression in Streptomyces albus and in vitro acetylation with resistance conveying ...
Aske Merrild +3 more
wiley +2 more sources
Novel Macrolactams from a Deep-Sea-Derived Streptomyces Species [PDF]
Marine Drugs, 2020 Four polyene macrolactams including the previously reported niizalactam C (4), and three new ones, streptolactams A–C (1–3) with a 26-membered monocyclic, [4,6,20]-fused tricyclic and 11,23-oxygen bridged [14,16]-bicyclic skeletons, respectively, were isolated from the fermentation broth of the deep-sea sediment-derived Streptomyces sp.
Pei Wang +6 more
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Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.An isocyanide‐based macrocyclization, involving the formation of a C(sp3)‐C(sp2) bond and the concurrent generation of an α‐acyloxy amide functional group, has been developed and successfully applied to the total synthesis of discobahamin A, a 24‐membered macrocyclopeptide. Abstract We report in this paper the first total synthesis of discobahamin A, a
Baochao Yang, Qian Wang, Jieping Zhu
wiley +2 more sources
Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi
Advanced Science, Volume 12, Issue 37, October 6, 2025.The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda +12 more
wiley +1 more source
DMAPO/Boc2O‐Mediated One‐Pot Direct N‐Acylation of Sulfoximines with Carboxylic Acids
European Journal of Organic Chemistry, Volume 28, Issue 33, September 20, 2025.The one‐pot direct N‐acylation of NH sulsoximines with carboxylic acids is described. The method can be performed under mild low‐temperature reaction conditions and exhibits a wide substrate scope (> 60 examples). The present method is operationally simple, scalable, and practical; thus, it can find wide applications in both academic and industrial ...
Atsushi Umehara +2 more
wiley +1 more source
Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid‐Free Analgesics
Angewandte Chemie, Volume 136, Issue 47, November 18, 2024.MD01‐67 is a macrocyclic analog designed to selectively target the neurotensin receptor type 2 (NTS2), identified through an in‐depth SAR study. Based on NT(7–12), in which Ile12 was substituted by cyclopentylalanine, Pro7 and Pro10 were replaced by allyl‐glycine, followed by side‐chain to side‐chain cyclization using ring‐closing metathesis, this ...
Michael Desgagné +8 more
wiley +2 more sources
Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster [PDF]
Nature Communications, 2013 Polycyclic tetramate macrolactams (PTMs) are a widely distributed class of natural products with important biological activities. However, many of these PTMs have not been characterized. Here we apply a plug-and-play synthetic biology strategy to activate a cryptic PTM biosynthetic gene cluster SGR810-815 from Streptomyces griseus and discover three ...
Luo, Yunzi +7 more
openaire +2 more sources