Structure‐activity profiles of macrolactam immunosuppressant FK‐506 analogues
FEBS Letters, 1993 The immunosuppressive agent FK‐506 has received much attention due to its efficacy and potency in the areas of transplant rejection and autoimmune disease. Calcineurin, a Ca2+‐calmodulin activated phosphatase, was recently implicated in the immunosuppressive mechanism of FK‐506.
Kawai, Megumi +5 more
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Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines [PDF]
Frontiers in Microbiology, 2018 Many bioactive natural products are glycosylated compounds in which the sugar components usually participate in interaction and molecular recognition of the cellular target. Therefore, the presence of sugar moieties is important, in some cases essential, for bioactivity.
Mónica G. Malmierca +15 more
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Highly Cytotoxic Cryptophycin Derivatives with Modification in Unit D for Conjugation
Angewandte Chemie International Edition, Volume 63, Issue 50, December 9, 2024.Cytotoxic cryptophycins with versatile conjugation handles in unit D are accessible by a highly efficient and scalable synthetic route. This ABC+D strategy enabled the creation of a vast array of cryptophycins leading to a quantitative structure activity relationship, allowing for the synthesis of most potent conjugable cryptophycin derivatives being ...
Cedric Dessin +7 more
wiley +1 more source
Reactivity Inside Molecular Flasks: Acceleration Modes and Types of Selectivity Obtainable
Angewandte Chemie International Edition, Volume 63, Issue 49, December 2, 2024.Molecular flasks are hollow supramolecular structures capable of catalyzing organic reactions, often exhibiting complex catalytic mechanisms and selectivity not achievable in bulk solvent. This Review discusses the different acceleration modes that operate within molecular flasks, and showcases the different types of selectivity that are obtainable ...
Leonidas‐Dimitrios Syntrivanis +1 more
wiley +1 more source
Synchronous intramolecular cycloadditions of the polyene macrolactam polyketide heronamide C
Chemical Communications, 2016 Two spontaneous intramolecular cycloadditions lead to the biosynthetic congeners heronamide A and B.
Booth, Thomas J. +3 more
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Polycyclic Tetramate Macrolactams and Their Potential as Anticancer Agents
OrganicsNatural products have been a reliable source of drug compounds in medical research. Technological advances have led to the discovery and characterization of many compounds that were previously difficult to isolate. However, when searching for anticancer drugs, finding natural compounds that can bind to specific targets is a daunting task.
Alexandria Montavon +2 more
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Heronamides G–L, polyene macrolactams from Streptomyces niveus
RSC Advances, 2018 New polyene macrolactams, heronamides G–L (1–6) from the fermentation broth of Streptomyces niveus.
Nan Ding +9 more
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A plug-and-play system for polycyclic tetramate macrolactam production and functionalization
Microbial Cell FactoriesAbstract Background The biosynthesis of the natural product family of the polycyclic tetramate macrolactams (PoTeMs) employs an uncommon iterative polyketide synthase/non-ribosomal peptide synthetase (iPKS/NRPS). This machinery produces a universal PoTeM biosynthetic precursor that contains a tetramic acid moiety ...
Anna Glöckle +3 more
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Diastereoselective synthesis of cyclic tetrapeptide pseudoxylallemycin A illuminates the impact of base during macrolactamization. [PDF]
Org Biomol Chem, 2023 Fumo VM +3 more
europepmc +1 more source
Biosynthesis of Macrolactam Antibiotics in Actinomycetes
Biosynthesis of Macrolactam Antibiotics in Actinomycetesidentifier:oai:t2r2.star.titech.ac.jp ...
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