Multiplex PCR to Diagnose Gastrointestinal Infections: Key Limitations in Interpretation
ABSTRACT Multiplex polymerase chain reaction (PCR) panels are increasingly used for the evaluation of acute diarrhea, providing rapid and sensitive detection of a broad range of enteric pathogens. However, their widespread adoption has created important interpretive challenges for clinicians.
Giannoula S. Tansarli, Ferric C. Fang
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Association of doxycycline treatment with time to first documented MP-RNA negative conversion in pediatric Mycoplasma pneumoniae pneumonia: a retrospective cohort study. [PDF]
Lian D, Wei J, Xie M, Lin C, Tang Q.
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The 2:1 chlorhexidine–clotrimazole combination demonstrated enhanced antibacterial activity against canine Staphylococcus pseudintermedius isolates, including resistant strains. Reduced MIC values, predominantly additive interactions and absence of antagonism support its use as a promising topical strategy for canine pyoderma management.
Brenda Gallegos‐Torres +3 more
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Veterinary macrolides against <i>Streptococcus agalactiae</i>: antibacterial basis, resistance determinants, and PK/PD implications. [PDF]
Liu H +7 more
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Successful Treatment of Mycobacterium caprae Infection in Two UK Cats
This article describes the first cases of successful treatment and long term resolution of clinical signs of two cats infected with Mycobacterium caprae. This suggests that the “triple antibiotics therapy” (rifampicin, azithromycin and pradofloxacin) used for other Mycobacterium tuberculosis‐complex infections in cats can be used safely and effectively
Emily Clark +2 more
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Convergent Synthesis of the Minimal Macrolide Antibiotic Narbomycin. [PDF]
Edmondson Q +5 more
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This study investigated the prevalence and antibiotic resistance of Staphylococcus aureus isolated from bovine mastitis in Bardaghat Municipality, Nepal. Screening 196 milk samples revealed a 39.79% prevalence of S. aureus, with 100% of the isolates exhibiting resistance to oxacillin, indicating the widespread presence of MRSA.
Biswash Ghimire +5 more
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Associations of Mycoplasma pneumoniae load, co-infections, and macrolide resistance with clinical-laboratory profiles in hospitalized pediatric pneumonia: a targeted next-generation sequencing study of bronchoalveolar lavage fluid. [PDF]
Liang X +15 more
europepmc +1 more source
Metagenomics revealed distinct anthropogenic signatures in the microbiome of freshwater sources on Marambaia Island, supported by the Anthropogenic Impact Index (AII). Impacted sites showed lower microbial diversity, enrichment of fecal‐associated taxa, and 14 antimicrobial resistance genes, whereas conductivity, salinity, and turbidity explained 88.1%
Bruna Barbosa de Paula +6 more
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AGXX enhances aminoglycoside activity against multidrug‐resistant pathogens such as uropathogenic Escherichia coli by increasing reactive oxygen species, causing protein aggregation and DNA damage. This effect is reduced by oxygen limitation or antioxidants. Polyphosphate protects cells from oxidative damage.
Emmanuel P. Oladokun +9 more
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