Results 191 to 200 of about 2,246,897 (273)

Empirical Meropenem Versus Piperacillin/Tazobactam for Critically Ill Adults With Sepsis: Feasibility of a Randomised Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
ABSTRACT Background Meropenem and piperacillin/tazobactam are commonly used empirical antibiotics in critically ill adults with sepsis, but whether one is superior to the other is uncertain. Methods The Empirical Meropenem versus Piperacillin/Tazobactam for Adult Patients with Sepsis (EMPRESS) trial is an ongoing investigator‐initiated, randomised ...
Nick Frørup Meier, Morten Hylander Møller, Maj‐Brit Nørregaard Kjær, Fredrik Sjövall, Marie Warrer Munch, Benjamin Skov Kaas‐Hansen, Hans‐Christian Thorsen‐Meyer, Bodil Steen Rasmussen, Marie Helleberg, Frederik Boëtius Hertz, Theis Lange, Aksel Karl Georg Jensen, Lars Wiuff Andersen, Jakob Steen Andersen, Jens Michelsen, Lars Peter Kloster Andersen, Morten Heiberg Bestle, Anne Craveiro Brøchner, Theis Skovsgaard Itenov, Steffen Christensen, Ronni Thermann Reitz Plovsing, Klaus Ulrik Koch, Anders Møller, Olav Lilleholt Schjørring, Naia Bech Cranø, Kasper Vamdrup‐Andersen, Davide Placido, Tine Sylvest Meyhoff, Carl Thomas Anthon, Aske Tøgern, Milda Grigonyte‐Daraskeviciene, Zemira Engbakken, Anne Witte Kamstrup, Kis Rønn Uhre, Jehad Ahmad Barakji, Rikke Faebo Larsen, Anders Perner, Anders Granholm   +37 more
wiley   +1 more source

Clinical Evaluation of Omadacycline for Pulmonary Mycobacterium <i>abscessus</i> Complex Infections: A Subgroup Analysis With a Focus on Macrolide Resistance. [PDF]

CHEST Pulm
Al Musawa M, El Ghali A, Bean R, Mammadova M, Wadle C, Muscarella A, Cimino C, Zeuli J, Howard C, Butt S, Mejia-Chew C, Kaip EA, Tupayachi-Ortiz MG, Fiske CT, Judd C, Caniff KE, Rybak MJ.   +16 more
europepmc   +1 more source

Patch Testing in Paediatric Drug Hypersensitivity Reactions: Current Evidence and Clinical Implications

Contact Dermatitis, Volume 95, Issue 4, Page 349-357, October 2026.
ABSTRACT Drug hypersensitivity reactions (DHRs) are common in children and are diagnostically challenging, with cutaneous manifestations being the most common presentation. Patch testing (PT) is a well‐established tool for investigating delayed T‐cell‐mediated reactions and is widely used in patients with contact dermatitis.
Gabriele Simonetti, Francesco Catamerò, Giulia Liccioli, Leonardo Tomei, Simona Barni, Mattia Giovannini, Lucrezia Sarti, Francesca Mori   +7 more
wiley   +1 more source

Efflux-Mediated Macrolide Resistance in Clinical <i>Streptococcus</i> Isolates: A Comparative Molecular Study. [PDF]

Antibiotics (Basel)
Moshewh SM, Mohamed SE, Kumar P, Eltom AE, Jagdale SR, Osman EA, Ahmed SS, Farajallah NAM, Ali S.   +8 more
europepmc   +1 more source

Associations of Serum CIRP and CXCL5 With Prognosis and Neutrophil Extracellular Traps in Pediatric Mycoplasma pneumoniae Pneumonia

The Clinical Respiratory Journal, Volume 20, Issue 10, October 2026.
This study investigated serum levels of cold‐inducible RNA‐binding protein (CIRP) and C‐X‐C motif chemokine ligand 5 (CXCL5) in 485 children with Mycoplasma pneumoniae pneumonia. Elevated levels of both biomarkers were independently associated with poor prognosis and positively correlated with neutrophil extracellular trap markers, suggesting their ...
Litao Wan, Bolin Liu, Ning Xie, Jianhua Li, Ting Su, Liyan Zhang, Xiaohua Wang, Shiding Gao   +7 more
wiley   +1 more source

Beyond Ribosomal Mutations: Identification of <i>MPN_080</i> as a Novel ATPase-Dependent Determinant of Macrolide Resistance in <i>Mycoplasma pneumoniae</i>. [PDF]

Microorganisms
Li S, Xia Y, Zhao F, Wang X, Li Z, Liu L, Liu J, Diao M.   +7 more
europepmc   +1 more source

Epidemiological Characteristics and Clinical Impact of Macrolide‐Resistant Mycoplasma pneumoniae Infection in Children in Southwest China, 2021–2025

The Clinical Respiratory Journal, Volume 20, Issue 10, October 2026.
This study reveals a persistently high macrolide resistance rate (87.87%) in Mycoplasma pneumoniae among children in Southwest China (2021–2025), predominantly affecting those aged 2–8 years. MRMP infections are associated with longer hospital stays, increased bronchoscopy use, and higher doxycycline prescriptions, underscoring the urgent need for ...
Ting Liu, Sha‐sha Chen, Xiao‐lin Chen, Si‐yu Tan, Qin‐xue Lu, Yan Zhou   +5 more
wiley   +1 more source

Analysis of Macrolide Resistance in Bordetella pertussis Isolated from Japanese Children in 2025 Using Test Kit and Sequence Method. [PDF]

Biomedicines
Oishi T, Nakano T.
europepmc   +1 more source

Updates in COPD Management: From Inflammatory Pathways to Targeted Therapies

European Journal of Clinical Investigation, Volume 56, Issue 10, October 2026.
COPD is a heterogeneous disease driven by overlapping neutrophilic and eosinophilic inflammatory pathways. This review highlights the shift from symptom‐based treatment toward phenotype‐ and biomarker‐directed care. Blood eosinophils, FeNO, and IgE predict corticosteroid responsiveness and identify candidates for biologic therapy.
Sasha Raman, Sreya Rahman, Francesca Polverino, Muhammad Adrish   +3 more
wiley   +1 more source

Molecular epidemiology and increasing macrolide resistance of Bordetella pertussis isolates in Guangzhou, China. [PDF]

BMC Infect Dis
Mai Q, Wen J, Luo Y, Guo J, Qin Y, Lai W, Deng W, Ji C, Mai R, Zheng M, Chen Z, Chen Y, Gu C, Guo L, Li H, Tang Y, Huang D, Luo M.   +17 more
europepmc   +1 more source