Results 81 to 90 of about 544,173 (300)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Summary report of reviewer comments on the report on public health implications of hazardous substances in the twenty-six U.S. Great Lakes areas of concern [PDF]
Submitted to the Agency for Toxic Substances and Disease Registry by ERG, Inc.PeerReview.pdfSection 1. Peer Reviewers' Summary Reports on Document -- Section 2. Additional References and Data Submitted by the Peer Reviewers -- Section 3. Annotated Pages
core
RIBFIND: a web server for identifying rigid bodies in protein structures and to aid flexible fitting into cryo EM maps [PDF]
, 2012 Motivation: To better analyze low-resolution cryo electron microscopy maps of macromolecular assemblies, component atomic structures frequently have to be flexibly fitted into them.
Topf, Maya +3 more
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Ultra rapid approaches to mild macromolecular conjugation
, 2010 In light of the increasing demand for ultra rapid and mild conjugation chemistries for use in macromolecular chemistry, the present Feature Article provides a critical overview of the very latest developments in this field.
Christopher Barner‐Kowollik +3 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
, 2007 Macroscopic and macromolecular material design and their influence on hydrolysis mechanism of poly(epsilon-caprolactone) (PCL) was evaluated. Homogoenous discs of linear PCL, porous scaffolds of linear PCL and crosslinked PCL networks were subjected to ...
Hakkarainen, Minna, +2 more
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The effect of pH, dissolved humic substances, and ionic composition on the transfer of iron and phosphate to particulate size fractions in epilimnetic lake water. [PDF]
, 1994 Transformations of dissolved iron and phosphate to particulate material (>0.2 \mu m) were investigated by adding ^55 FeCl_3, and ^32 PO_4^3- to pH adjusted epilimnetic lake water samples of contrasting ionic strengths and dissolved humic substances ...
Peter J. Shaw, Shaw, Peter J.
core +1 more source