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Emapalumab as a Life-Saving Therapy for Macrophage Activation Syndrome in Refractory Systemic Juvenile Idiopathic Arthritis with Trisomy 21. [PDF]

Turk Arch Pediatr
Akay N, Aslan E, Gul U, Kilic Konte E, Yildiz M, Sahin S.   +5 more
europepmc   +1 more source

Clinical features and comorbidities of Epstein-Barr virus infection in childhood-onset systemic lupus erythematosus with a focus on macrophage activation syndrome: a cross-sectional study of 200 patients. [PDF]

Front Immunol
Wang H, Zhouyang M, Yang X, Zhang J, Yan H, Zhang Y, Li L, Zhao B.   +7 more
europepmc   +1 more source

A CROP-seq screen of histone modifying enzymes reveals histone demethylase Kdm5c regulates inflammatory macrophage activation

Horstman F, Griffith GR, Vinciguerra F, Siebeler R, van Roomen C, Kuznetsova T, Sluimer JC, Pasterkamp G, Mokry M, de Winther MP, Prange KH.   +10 more
europepmc   +1 more source

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Activation of macrophages

Comparative Immunology, Microbiology and Infectious Diseases, 1985
The role of macrophages is essential in the development of a normal immune response. Not only are these cells involved in the initiation of this response by presenting antigens to lymphocytes and by producing Interleukin I, but they also participate in the various phenomena of cellular co-operation and regulation.
E, Schneider, M, Dy
openaire   +2 more sources

N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation.

Cellular Signalling, 2020
Macrophage polarization is the driving force of various inflammatory diseases, especially those involved in M1/M2 imbalance. N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in eukaryotes that affects multiple biological ...
Xiaofei Gu, Yiwen Zhang, Di Li, H. Cai, Luhui Cai, Qiong Xu   +5 more
semanticscholar   +1 more source

Macrophage activation syndrome

Current Opinion in Rheumatology, 2002
Macrophage activation syndrome (MAS) is a serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of T lymphocytes and macrophages. Recent findings in hemophagocytic lymphohistiocytosis, a disease that is clinically similar to MAS, highlight the possible pathogenetic role ...
openaire   +3 more sources

Regulation of macrophage activation

Cellular and Molecular Life Sciences (CMLS), 2003
IFN-gamma rapidly primes the macrophage via JAK1/2-STAT1 pathway so that it can subsequently undergo a slower classical type 1 activation upon exposure to T helper (Th)1 cytokines such as IFNgamma or other activators, including tumor necrosis factor and lipopolysaccharide, e.g. in intracellular killing of phagocytosed Mycobacterium tuberculosis.
J, Ma, T, Chen, J, Mandelin, A, Ceponis, N E, Miller, M, Hukkanen, G F, Ma, Y T, Konttinen   +7 more
openaire   +2 more sources