Results 341 to 350 of about 4,994,603 (399)

Polarized Activation of Macrophages

2014
Macrophages are mononuclear phagocytes which play important roles in many aspects of immunity, tissue repair and metabolism. Plasticity is a key feature of these cells and consists in the capability to modulate their phenotypic and functional aspects under distinct stimuli derived from the microenvironment. A number of transcription factors, epigenetic
Galdiero, M. R., Biswas, S. K., Mantovani, A.   +2 more
openaire   +2 more sources

Activation of macrophages for antimycobacterial activity

Immunology Letters, 1985
The role of macrophage hydrogen peroxide in defense against mycobacterial infection is discussed - not because this is necessarily any more important than other macrophage products (reviews: [1, 2]) but more as a reflection of recently available information.
D B, Lowrie, P S, Jackett, P W, Andrew
openaire   +2 more sources

Macrophage Activation Syndrome

Arthritis & Rheumatology
Macrophage activation syndrome (MAS) is a state of immune hyperactivation that can result in life‐threatening multisystem end‐organ dysfunction. Often termed a “cytokine storm,” MAS occurs among the rheumatic diseases most typically in Still's disease but also in systemic lupus erythematosus and Kawasaki disease.
openaire   +2 more sources

Arginine and Macrophage Activation

2011
In order to perform their functions, macrophages must be activated either by Th1-type cytokines, such as interferon-gamma which is called classical activation or M1, or by Th2-type cytokines, such as IL-4, IL-10, IL-13, etc. referred as alternative activation or M2.
Comalada, M., Yeramian, A., Modolell, M., Lloberas, J., Celeba, A.   +4 more
openaire   +3 more sources

Interferon Activates Macrophages to Produce Plasminogen Activator

Journal of Interferon Research, 1982
Macrophages and monocytes become activated, by a variety of mechanisms, to exhibit cytotoxicity. Associated with this activation for cytotoxicity is the production of certain neutral proteases, especially plasminogen activator (PA), which may be involved in the mechanism of cytolysis.
C M, Jones, L, Varesio, R B, Herberman, S, Pestka   +3 more
openaire   +2 more sources

Mycobacteria and macrophage activation

Research in Microbiology, 1990
Recent studies that challenged some older concepts have led to the following conclusions: 1) During an infection of mice with M. bovis, BCG macrophages are activated according to certain criteria, but the increase in their bactericidal or bacteriostatic activity is limited to a small number of bacteria species; 2) interferon-gamma can activate ...
openaire   +2 more sources

Alternative activation of macrophages

Nature Reviews Immunology, 2003
The classical pathway of interferon-gamma-dependent activation of macrophages by T helper 1 (T(H)1)-type responses is a well-established feature of cellular immunity to infection with intracellular pathogens, such as Mycobacterium tuberculosis and HIV.
openaire   +2 more sources

Chondrocytes may activate macrophages

Experimental pathology, 1991
It is demonstrated that conditioned media of articular chondrocytes cultured with Bacilli Calmette-Guérin are capable of activating macrophages. This activation reaches different levels and is expressed both by different cell survival and enhanced synthesis of glycosaminoglycans that remain cell-associated (exp. group III) or are secreted (exp.
openaire   +2 more sources

Activation of Murine Macrophages

Current Protocols in Immunology, 1994
AbstractMacrophages can act as potent effector cells of the immune response. Cytokine signals generated during an immune response activate macrophages in a complex cascade of events. Activated macrophages are qualitatively different from mature resident tissue macrophages and from immature inflammatory macrophages.
openaire   +2 more sources

Regulators of macrophage activation

European Journal of Immunology, 2011
AbstractMacrophages are ubiquitous phagocytes that can constitute up to 15% of the cellular content of tissues. These heterogeneous cells of the innate immune system perform important functions during health and disease. Equipped with receptors for the T helper cell cytokines INF‐γ and IL‐4, macrophages undergo specific activation programs during Th1 ...
openaire   +2 more sources