Results 141 to 150 of about 261,254 (319)

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Makrofag Pengekspresi Il-1? Serta Respons Inflamasi Sistemik Pada Fiksasi Interna Dini Fraktur Femur Tertutup Lebih Rendah Dibandingkan Dengan Yang Tertunda [PDF]

, 2007
Fiksasi interna merupakan salah satu modalitas terapi dalam penangananfraktur. Fiksasi interna dini dan tertunda masih menjadi suatu perdebatan karenaadanya perbedaan komplikasi yang ditimbulkan, terutama yang berhubungandengan respons inflamasi sistemik.
Astawa, P. (P), Bakta, M. (M), K, B. (Budha)   +2 more
core  

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

An Unusual Case of Macrophage Activation Syndrome (MAS)- Hemophagocytic Lymphohistiocytosis (HLH) Triggered by Necrotizing Autoimmune Myopathy [PDF]

, 2023
Tyiesha S Brown, Gregory Vo, Prangthip Charoenpong   +2 more
openalex   +1 more source

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

Macrophage activation syndrome(MAS) refractory to immunoglobulin with excellent response to rituximabe: case report

, 2021
Douglas Squizatto Leite, Matheus Zanata Brufatto, Sean Hideo Shirata Lanças, Andréa de Almeida Peduti Batista, Laura Maria Silva de Siqueira, Henrique Pereira Sampaio, Luiz Eduardo Valente, Daniela Esteves Temporim, João Flávio Gomes Faria, Sula Glaucia Lage Drumond Pacheco   +9 more
openalex   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

Macrophage Activation Syndrome

Clinical Pediatrics, 2016
Courtney B, Crayne, Kourosh S, Khatami, Gretchen, Galliano   +2 more
openaire   +3 more sources

MACROPHAGE ACTIVATION SYNDROME IN A PATIENT WITH A RECENT DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS – A REPORT OF SUCCESSFUL TREATMENT WITH DEXAMETHASONE AND HUMAN IMMUNOGLOBULIN

, 2022
Evelyn Joyce Corgosinho, Marcella Maria Soares Mello, Beatriz Mota Tiburcio, Larissa Andrade Lourenço, Camila Martins Lopes, Cézar Gonçalves de Carvalho, Úrsula Silva Teixeira   +6 more
openalex   +1 more source

Addressing the treatment of macrophage activation syndrome: A challenging balance between immune suppression and infectious risk [PDF]

, 2022
V Vassia, A Iannaccone, S Marengo, A Briozzo, A Brussino, Lucrezia Alessi, L Brussino, C Norbiato   +7 more
openalex   +1 more source