Results 141 to 150 of about 256,905 (322)

LP-112 A case of macrophage activation syndrome in neonatal lupus [PDF]

, 2023
Jung Woo Rhim, Soo Young Lee, Hyun Mi Kang, Ye Ji Kim, In Hyuk Lyu, Dae-Chul Jeong   +5 more
openalex   +1 more source

Fanconi Mutation in Macrophage Activation Syndrome [PDF]

Indian Journal of Pediatrics, 2021
Sidharth Yadav, Anu Maheshwari, Shreshtha Kaushik, Deonath Mahto   +3 more
openaire   +2 more sources

Macrophage Activation Syndrome in MIS-C

Pediatrics
BACKGROUND Multisystem inflammatory syndrome (MIS-C) represents a diagnostic challenge because of its overlap with Kawasaki disease, Kawasaki disease shock syndrome, and toxic shock syndrome. Macrophage activation syndrome (MAS) is a frequently fatal complication of various pediatric inflammatory disorders and has ...
Luisa Berenise, Gámez-González, Chiharu, Murata, Jimena, García-Silva, Rolando, Ulloa-Gutierrez, Martha, Márquez-Aguirre, Itzel, Ríos-Olivares, Enrique, Faugier-Fuentes, Jesús A, Domínguez-Rojas, Adriana, Yock-Corrales, Martha I, Álvarez-Olmos, Jaime, Fernández-Sarmiento, Mónica, Velasquez-Méndez, Gabriela, Ivankovich-Escoto, Adriana H, Tremoulet, Marco A, Yamazaki-Nakashimada   +14 more
openaire   +3 more sources

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

Multiscale Construction, Evaluation, and Application of Organoids

Advanced Science, EarlyView.
Organoids are pivotal models with transformative biomedical potential. A comprehensive multi‐scale perspective is presented, encompassing dual‐scale construction, four‐dimensional evaluation, triple‐point application, and an analysis of the current challenges faced by organoid technology, aiming to advance organoid research and its biomedical ...
Wanting Ma, Zhenglin Dong, Zhu'anzhen Zheng, Long Bai, Xingcai Zhang, Jiacan Su   +5 more
wiley   +1 more source

Macrophage activation syndrome: A cause of unresponsive malaria

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Macrophage activation syndrome (MAS) results from inappropriate proliferation and activation of cells of the macrophage-histiocytic lineage. Severe infections, autoimmune diseases and malignancies are known to trigger MAS in otherwise healthy individuals.
Manish Bhagat, Sujata Kanhere, Purvi Kadakia, Varsha Phadke, Riya George, Kushagra Chaudhari   +5 more
doaj  

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, EarlyView.
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Successful control of juvenile dermatomyositis-associated macrophage activation syndrome and interstitial pneumonia: distinct kinetics of interleukin-6 and -18 levels [PDF]

, 2015
Hiroyuki Wakiguchi, Shunji Hasegawa, Reiji Hirano, Hidenobu Kaneyasu, Midori Wakabayashi‐Takahara, Shouichi Ohga   +5 more
openalex   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, EarlyView.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source