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Emapalumab in Patients With Macrophage Activation Syndrome Associated With Still's Disease: A Population Pharmacokinetic/Pharmacodynamic Analysis. [PDF]
Clin Transl SciBrossard P.
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Macrophage Activation Syndrome in Children: Update on Diagnosis and Treatment. [PDF]
Children (Basel)Lee J +5 more
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MACROPHAGE ACTIVATION SYNDROME
Journal of Clinical Gastroenterology, 2011We recently treated a patient with adult-onset Still's disease who developed macrophage activation syndrome (MAS) secondary to disseminated histoplasmosis while being treated with adalimumab. The gastroenterology service was consulted early, before diagnosis, as the patient presented with elevated liver enzymes and disseminated intravascular ...
Bijal A, Jayakar, Philip J, Hashkes
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The genetics of macrophage activation syndrome
Genes & Immunity, 2020Macrophage activation syndrome (MAS), or secondary hemophagocytic lymphohistiocytosis (HLH), is a cytokine storm syndrome associated with multi-organ system dysfunction and high mortality rates. Laboratory and clinical features resemble primary HLH, which arises in infancy (1 in 50,000 live births) from homozygous mutations in various genes critical to
Grant S, Schulert, Randy Q, Cron
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Macrophage activation syndrome in pediatrics
Pediatric Allergy and Immunology, 2020AbstractMacrophage activation syndrome (MAS) is a serious, potentially life‐threatening, hyperinflammatory condition, which belongs to the spectrum of hemophagocytic lymphohistiocytosis (HLH) and can complicate several immunologic and rheumatic disorders.
Alongi, Alessandra +4 more
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Macrophage Activation Syndrome
Arthritis & RheumatologyMacrophage activation syndrome (MAS) is a state of immune hyperactivation that can result in life‐threatening multisystem end‐organ dysfunction. Often termed a “cytokine storm,” MAS occurs among the rheumatic diseases most typically in Still's disease but also in systemic lupus erythematosus and Kawasaki disease.
Sonia Iosim, Lauren A. Henderson
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Macrophage activation syndrome in malaria
Rheumatology International, 2009Macrophage activation syndrome (MAS) is a clinical syndrome caused by an excessive proliferation of T lymphocytes and well-differentiated macrophages; an entity distinct from malignant histiocytosis. Although rheumatologic conditions are the common cause of MAS, a wide range of infections are also seen to cause MAS.
Rashna, Dass +6 more
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Macrophage activation syndrome
Current Opinion in Rheumatology, 2002Macrophage activation syndrome (MAS) is a serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of T lymphocytes and macrophages. Recent findings in hemophagocytic lymphohistiocytosis, a disease that is clinically similar to MAS, highlight the possible pathogenetic role ...
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A rare trigger for macrophage activation syndrome
Rheumatology International, 2009Macrophage activation syndrome (MAS) is a disorder characterized by increased activation of mononuclear cells leading to phagocytosis of blood cell precursors in the bone marrow. We describe a case of MAS triggered by disseminated histoplasmosis occurring in a patient with Still's disease on long-term treatment with adalimumab.
Shikhar, Agarwal +5 more
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Kawasaki disease shock syndrome and macrophage activation syndrome
Paediatrics and International Child Health, 2018We thank Han and Lee [1] for their comments and interest in our case report [2]. They report a patient similar to ours in terms of clinical presentations but who had a final diagnosis of Kawasaki d...
Hui-Fang Yang, Hueng-Chuen Fan
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