Results 51 to 60 of about 551,256 (383)

The in silico macrophage: toward a better understanding of inflammatory disease [PDF]

Genome Medicine 2011, 3:4 (22 January 2011), 2011
Macrophages function as sentinel, cell-regulatory hubs capable of initiating, perpetuating and contributing to the resolution of an inflammatory response, following their activation from a resting state. Highly complex and varied gene expression programs within the macrophage enable such functional diversity.
arxiv   +1 more source

Neutralization of IFN-γ reverts clinical and laboratory features in a mouse model of macrophage activation syndrome. [PDF]

, 2018
BACKGROUND: The pathogenesis of macrophage activation syndrome (MAS) is not clearly understood: a large body of evidence supports the involvement of mechanisms similar to those implicated in the setting of primary hemophagocytic lymphohistiocytosis ...
Bracaglia, Claudia, Caiello, Ivan, Chatel, Laurence, De Min, Cristina, Fabrizio De Benedetti, And, Ferlin, Walter G., Grom, Alexei A., Marasco, Emiliano, Pascarella, Antonia, Prencipe, Giusi, Strippoli, Raffaele   +10 more
core   +1 more source

Exploring Macrophage Activation Syndrome Secondary to Systemic Lupus Erythematosus in Adults: A Systematic Review of the Literature

Cureus, 2021
Among the autoimmune (AI) diseases, systemic lupus erythematosus (SLE) is known to mimic various disease processes and this can lead to under-diagnosis of macrophage activation syndrome (a dire complication). We aimed at performing a systematic review to
Afia Aziz, E. Castaneda, Noorain Ahmad, Harish Veerapalli, Amy G Rockferry, Chetan Reddy Lankala, Pousette Hamid   +6 more
semanticscholar   +1 more source

Macrophage activation syndrome in systemic lupus erythematosus - a case report

Journal of Education, Health and Sport, 2023
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition that results from the immune system hyperactivation. The primary form of HLH appears mainly in children and is caused by a genetically determined failure of NK and T cells ...
Maciej Rogala, Karol Lorenc, Klaudia Jabłońska, Michał Kuc, Olga Bielawska, Tomasz Łoś, Kamila Giżewska, Marta Gulbicka   +7 more
doaj   +1 more source

Parasite excretory-secretory products and their effects on metabolic syndrome [PDF]

, 2017
Obesity, one of the main causes of metabolic syndrome (MetS), is an increasingly common health and economic problem worldwide, and one of the major risk factors for developing type 2 diabetes and cardiovascular disease. Chronic, low-grade inflammation is
Crowe, J., Harnett, M.M., Harnett, W., Lumb, F.E.   +3 more
core   +2 more sources

Neuropathology in COVID-19 autopsies is defined by microglial activation and lesions of the white matter with emphasis in cerebellar and brain stem areas

Frontiers in Neurology, 2023
IntroductionThis study aimed to investigate microglial and macrophage activation in 17 patients who died in the context of a COVID-19 infection in 2020 and 2021.MethodsThrough immunohistochemical analysis, the lysosomal marker CD68 was used to detect ...
Julian A. Stein, Manuel Kaes, Sigrun Smola, Sigrun Smola, Walter J. Schulz-Schaeffer   +4 more
doaj   +1 more source

In silico prediction of protein-protein interactions in human macrophages [PDF]

BMC Research Notes, BioMed Central, 2014, 7, pp.157, 2015
Background: Protein-protein interaction (PPI) network analyses are highly valuable in deciphering and understanding the intricate organisation of cellular functions. Nevertheless, the majority of available protein-protein interaction networks are context-less, i.e.
arxiv   +1 more source

2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis

Annals of the Rheumatic Diseases, 2016
To develop criteria for the classification of macrophage activation syndrome (MAS) in patients with systemic juvenile idiopathic arthritis (JIA). A multistep process, based on a combination of expert consensus and analysis of real patient data, was ...
A. Ravelli, F. Minoia, S. Davì, A. Horne, F. Bovis, A. Pistorio, M. Aricò, T. Avčin, Edward M. Behrens, F. De Benedetti, Lisa Filipovic, A. Grom, J. Henter, Norman T. Ilowite, Michael B Jordan, R. Khubchandani, T. Kitoh, K. Lehmberg, D. Lovell, P. Miettunen, Kim E Nichols, S. Ozen, J. Pachlopnik Schmid, A. Ramanan, R. Russo, R. Schneider, G. Sterba, Y. Uziel, C. Wallace, C. Wouters, N. Wulffraat, E. Demirkaya, H. Brunner, A. Martini, N. Ruperto, R. Cron   +35 more
semanticscholar   +1 more source

Macrophage Activation Syndrome secondary to Systemic Juvenile Idiopathic Arthritis: A Case Report

Journal of Nepal Medical Association, 2021
Macrophage activation syndrome is a rare but a life threatening condition commonly associated with Systemic Juvenile Idiopathic Arthritis. Its clinical presentation includes fever, hepatosplenomegaly, hypertriglyceridemia, hypofibrinogenemia ...
Rishikesh Kafle, Anwesh Bhatta, Sumit Gami, Abhin Sapkota, Dipesh Sharma, Arabindra Yadav, Vijaya Kumar Chikanbanjar   +6 more
doaj   +1 more source

Systematic review: macrophage activation syndrome in inflammatory bowel disease [PDF]

, 2013
BACKGROUND: Recently, there have been increasingly frequent reports on the occurrence of macrophage activation syndrome (MAS) in patients with inflammatory bowel disease (IBD).
CASCIO, ANTONIO, COTTONE, Mario, Fries W
core   +1 more source