Results 61 to 70 of about 3,030,015 (277)

Membrane changes in murine macrophages after in-vivo stimulation and activation [PDF]

, 1983
The expression of various receptors and other surface determinants on resident, glycogen-and Corynebacterium parvum- elicited mouse peritoneal macrophages has been described.
GLASS, EJ, WEIR, DM, STEWART, J
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Line-selective macrophage activation with an anti-CD40 antibody drives a hemophagocytic syndrome in mice [PDF]

, 2020
Hemophagocytic syndromes comprise a cluster of hyperinflammatory disorders, including hemophagocytic lymphohistiocytosis and macrophage activation syndrome.
Pfefferlé, Marc, Dubach, Irina L, Yalamanoglu, Ayla, Humar, Rok, Schaer, Christian A, Hansen, Kerstin, Vallelian, Florence, Ingoglia, Giada, Valkova, Kristyna, Schaer, Dominik J, Schulthess, Nadja, Valkova K, Pfefferlé M, Schulthess N, Schaer DJ, Yalamanoglu A, Dubach IL, Vallelian F, Humar R, Hansen K, Ingoglia G, Schaer CA   +21 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Plasma Ferritin as Marker of Macrophage Activation-Like Syndrome in Critically Ill Patients With Community-Acquired Pneumonia

, 2021
OBJECTIVES: Plasma ferritin levels above 4,420 ng/mL have been proposed as a diagnostic marker for macrophage activation-like syndrome in sepsis and used for selection of sepsis patients for anti-inflammatory therapy.
MARS Consortium, Epi Infectieziekten, JC onderzoeksprogramma Infectious Diseases, Medische Staf Intensive Care, Infection & Immunity   +4 more
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Recurrent Episodes of Acute Pancreatitis as an Initial Presentation of Systemic Lupus Erythematosus and Autoimmune-Associated Hemophagocytic Syndrome

JK Science, 2023
Acute pancreatitis (AP) is a rare but fatal complication of systemic lupus erythematosus (SLE). A 40-year-old male presented with high-grade intermittent fever, abdominal pain & painless oral ulcers. Investigations revealed features suggestive of AP and
Siba Prasad Dalai, Pooja Uppu, Shrey Aradhye, Brijesh Raj Swain, Mrunmaya Ricky Jena, Chandan Das   +5 more
doaj  

Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans

Emerging Infectious Diseases, 2019
Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and ...
Anita K. McElroy, Punya Shrivastava-Ranjan, Jessica R. Harmon, Roosecelis B. Martines, Luciana Silva-Flannery, Timothy D. Flietstra, Colleen S. Kraft, Aneesh K. Mehta, G. Marshall Lyon, Jay B. Varkey, Bruce S. Ribner, Stuart T. Nichol, Sherif R. Zaki, Christina F. Spiropoulou   +13 more
doaj   +1 more source

First report of macrophage activation syndrome in hyperimmunoglobulinemia D with periodic fever syndrome

, 2007
We describe for the first time a case of macrophage activation syndrome in a child with hyperimmunoglobulinemia D with periodic fever syndrome who required intensive care support.
GENOVESE O, COMPAGNONE A, Ansuini, Valentina, RIGANTE D, Genovese, Orazio, CHIARETTI A, BERTONI B, STABILE A, PIASTRA M, Pulitano', Silvia Maria Modesta, CAPOLUONGO E., Chiaretti, Antonio, Rigante, Donato, Capoluongo, Ettore Domenico, Piastra, Marco, Stabile, Achille, ANSUINI V, PULITANO S   +17 more
core   +1 more source

Macrophage activation syndrome as an unusual presentation of paucisymptomatic severe acute respiratory syndrome coronavirus 2 infection

, 2020
Macrophage activation syndrome (MAS) is a rare life-threatening condition characterized by cytokine-mediated tissue injury and multiorgan dysfunction. We describe the unique case of young man who developed MAS as the sole manifestation of an otherwise ...
Serratrice, Jacques, Coen, Matteo, Lolachi, Sanaz, Jacques Serratrice, Sarah Morin, Alexandra Calmy, Calmy, Alexandra, Kaveh Samii, Sanaz Lolachi, Matteo Coen, Morin, Sarah, Samii, Kaveh, Lolachi S, Coen M, Morin S, Serratrice J, Samii K, Calmy A   +17 more
core   +1 more source