Results 81 to 90 of about 2,829,847 (276)

Macrophage activation syndrome, a rare complication of primary Sjögren’s syndrome: a case report

Journal of Medical Case Reports, 2019
Background The association of macrophage activation syndrome and primary Sjögren’s syndrome has been rarely reported in the literature. We report the first observation of this association in Africa, south of the Sahara, and we discuss the diagnosis and ...
B. S. Kane, M. Niasse, A. Faye, N. D. Diack, B. Djiba, M. Dieng, M. Sow, A. C. Ndao, N. Diagne, S. Ndongo, A. Pouye   +10 more
doaj   +1 more source

Role of sphingosine-1-phosphate receptor 1 and downstream heme oxygenase-1 induction in alternative macrophage activation induced by apoptotic cells [PDF]

, 2010
Macrophages show a remarkable functional plasticity, which enables them to change their phenotype in response to environmental signals. They are key players during infection by initiating inflammation through the release of proinflammatory mediators ...
Weis, Nicole
core  

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Macrophage Activation Syndrome in Juvenile Systemic Lupus Erythematosus A Multinational Multicenter Study of Thirty-Eight Patients

, 2009
Objective. To describe the clinical and laboratory features of macrophage activation syndrome as a complication of juvenile systemic lupus erythematosus (SLE).Methods.
Iglesias, Antonio, Espada, Graciela, Hayward, Kristen, Ruperto, Nicolino, Bader-Meunier, Brigitte, Ozen, Seza, Kristen Hayward, Dowain Wright, Magni-Manzoni, Silvia, Alberto Fischer, Magalhães, Cláudia Saad, Graciela Espada, Alexei Grom, Bracaglia, Claudia, Wouters, Carine, Khubchandani, Raju, Sergio Davì, Guseinova, Dinara, Paivi Miettunen, Claudia Saad Magalhães, Davi, Sergio, Sterba, Gary, Claudia Bracaglia, Marina Vivarelli, Seza Ozen, Miettunen, Paivi, Patricia Woo, Antonio Iglesias, Woo, Patricia, Raju Khubchandani, Alessandro Parodi, Gary Sterba, Michels, Hartmut, Alejandra Beatriz Pringe, Angela Pistorio, Alberto Martini, Martini, Alberto, Dinara Guseinova, Parodi, Alessandro, Hartmut Michels, Nicolino Ruperto, Vivarelli, Marina, Grom, Alexei, Magalhães, Cláudia Saad [UNESP], Carine Wouters, Beatriz Pringe, Alejandra, Angelo Ravelli, Breda, Luciana, Fischer, Alberto, Brigitte Bader‐Meunier, Luciana Breda, Ravelli, Angelo, Pistorio, Angela, Wright, Dowain, Silvia Magni‐Manzoni   +54 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Is synovial macrophage activation the inflammatory link between obesity and osteoarthritis?

, 2016
Osteoarthritis (OA) is the most common musculoskeletal disease, affecting nearly 25 % of the world population (WHO reports), leading to pain and disability.
Antonia RuJia Sun, Friis, Thor, Indira Prasadam, Prasadam, Indira, Crawford, Ross, Thor Friis, Xiao, Yin, Yin Xiao, Sekar, Sunderajhan, Ross Crawford, Sun, Antonia Rujia, Sunderajhan Sekar   +11 more
core   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Aging-associated Alteration in the Cardiac MIF-AMPK Cascade in Response to Ischemic Stress [PDF]

, 2008
An important role for a macrophage migration inhibitory factor (MIF)-AMP-activated protein kinase (AMPK) signaling pathway in ameliorating myocardial damage following ischemia/reperfusion has been described. An aging-associated reduction in AMPK activity
Lin Leng, Richard Bucala, Erin Lane, Heng Ma, Jingying Wang, Jun Ren, Wenkui Wang, Ji Li   +7 more
core  

Histopathological evidence for macrophage activation driving post‐transfusion hyperhaemolysis syndrome

, 2019
Post-transfusion hyperhaemolysis syndrome (PTHS) is a rare life-threatening transfusion complication reported mainly in sickle cell patients. Its pathogenesis is poorly understood.
Lucas, Sebastian, Sebastian Lucas, Rosie Hamilton, Ivan Robinson, Nay Win, Angela McKernan, Hebballi, Sangam, McKernan, Angela, Frederick Chen, Chen, Frederick, Win, Nay, Robinson, Ivan, Sangam Hebballi, Hamilton, Rosie   +13 more
core   +1 more source

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source