Results 91 to 100 of about 2,829,847 (276)

Macrophage Activation Syndrome: A Potentially Fatal Complication of Kawasaki Disease

The Turkish Journal of Gastroenterology, 2015
Kawasaki disease is an acute vasculitis of childhood. Macrophage activation syndrome is a rare life threatening complication. In this article, we report a five-year-six-month old girl patient with Kawasaki disease who developed irritability ...
Kallol BOSE, Sudip SAHA, Prabir SAHA, Piyasi MONDAL   +3 more
doaj  

First report of macrophage activation syndrome in hyperimmunoglobulinemia D with periodic fever syndrome

, 2007
We describe for the first time a case of macrophage activation syndrome in a child with hyperimmunoglobulinemia D with periodic fever syndrome who required intensive care support.
GENOVESE O, COMPAGNONE A, Ansuini, Valentina, RIGANTE D, Genovese, Orazio, CHIARETTI A, BERTONI B, STABILE A, PIASTRA M, Pulitano', Silvia Maria Modesta, CAPOLUONGO E., Chiaretti, Antonio, Rigante, Donato, Capoluongo, Ettore Domenico, Piastra, Marco, Stabile, Achille, ANSUINI V, PULITANO S   +17 more
core   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus [PDF]

, 2014
Several bacterial pathogens decorate their surfaces with sialic acid (Sia) residues within cell wall components or capsular exopolysaccharides. Sialic acid expression can promote bacterial virulence by blocking complement activation or by engagement of ...
Joshua Olson, Louie, Aaron, Crocker, Paul R., Victor Nizet, Aaron Louie, Ajit Varki, Paul R. Crocker, Varki, Ajit, Nizet, Victor, Yung-Chi Chang, Chang, Yung-Chi, Olson, Joshua   +11 more
core   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Unravelling the anti-inflammatory mechanisms of dietary fatty acids [PDF]

, 2009
Polyunsaturated fatty acids (PUFA) have been shown to modulate immune responses and have therapeutic effects in inflammatory disorders. The specific mechanisms of their actions have yet to be defined.
Dowling, Jennifer K.
core   +2 more sources

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signalling and functions [PDF]

, 2010
Leishmania alternates between two morphologically different stages: promastigotes and amastigotes. While the majority of reports focused on how the promastigote form can alter macrophage signalling and function, fewer reports investigated signalling ...
Hassani, K., Westra, E.R., Abu-Dayyeh, I., Edze R. Westra, Kasra Hassani, Issa Abu-Dayyeh, Mottram, J.C., Olivier, M., Jeremy C. Mottram, Martin Olivier   +9 more
core   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

A CLINICAL CASE OF SYSTEMIC JUVENILE ARTHRITIS COMPLICATED BY RECURRENT MACROPHAGE ACTIVATION SYNDROME AND CHRONIC OSTEOMYELITIS OF THE CLAVICLE

Научно-практическая ревматология, 2018
The paper describes a clinical case of severe systemic juvenile idiopathic arthritis (JIA) in a child with an early disease onset, which is resistant to multicomponent therapy (glucocorticoids, methotrexate, the tumor necrosis factor-α inhibitor ...
M. I. Kaleda, I. P. Nikishina, S. V. Arsenyeva   +2 more
doaj   +1 more source