Results 91 to 100 of about 3,030,015 (277)

MACROPHAGE ACTIVATION SYNDROME IN PATIENTS WITH SYSTEMIC JUVENILE ARTHRITIS [PDF]

, 2014
Macrophage activation syndrome (MAS) is one of the histiocytic diseases developing from cells of a macrophage series, hemophagocytic lymphohis- tiocytosis (HLH). Rheumatic diseases have been demonstrated to be often associated with the development of SAM,
S. R. Rodionovskaya, I. P. Nikishina
core   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Macrophage activation syndrome after initiation of corticosteroid and etanercept in a patient with adult onset still's disease

, 2008
Macrophage activation syndrome is a life threatening complication of rheumatic diseases. We report a patient with adult onset Still's disease who developed macrophage activation syndrome and serious infections after starting high dose steroid and ...
Lau, YL, Yip, CMS, Lee, TL, Chan, HB
core  

Macrophage Activation Syndrome as the Initial Manifestation of Systemic Lupus Erythematosus in a 7-Year-Old Girl – A Case Report. [PDF]

, 2017
 Macrophage activation syndrome (MAS) is a potentially fatal complication of several chronic rheumatic diseases. Although it occurs most commonly with systemic onset juvenile idiopathic arthritis (SoJIA), it may also occur in association with systemic ...
Akter, A H M Muslima, Rahman, Md Azizur, Begum, Afroza, Uddin, Golam Muin   +3 more
core   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Macrophage activation syndrome in an inadequately treated patient with systemic onset juvenile idiopathic arthritis

, 2014
Macrophage activation syndrome is a rare and potentially life threatening complication of childhood rheumatic disorders. It is described most commonly with systemic onset juvenile idiopathic arthritis (soJIA).
Juneja M, Jain R, Mishra D
core  

A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci [PDF]

, 2011
The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1.
Francis, S. E., Calogero Tulone, Read, R. C., Sheila E. Francis, Mitchell, T.J., Read Robert C., Benny Chain, Marriott, Helen M, Deretic, V., Dockrell, David H, Marriott, H.M., Francis, Sheila E, Dockrell, David H., Whyte, M.K.B., Martin A. Bewley, Mitchell Timothy J., Timothy J Mitchell, Whyte, Moira K B, Kroemer, G., Chain, B., Moira K. B. Whyte, Helen M Marriott, Sheila E Francis, Tulone Calogero, Robert C Read, Bewley, M.A., Dockrell, D.H., Whyte Moira K. B., Whyte, Moira K. B., Marriott Helen M., Read, Robert C., Marriott, H. M., Chain, Benny, Tulone, C., Read, R.C., Mitchell, Timothy J., Whyte, Moira K.B., David H. Dockrell, Mitchell, Timothy J, Francis Sheila E., David H Dockrell, Kroemer, Guido, Moira K B Whyte, Marriott, Helen M., Chain Benny, Mitchell, T. J., Timothy J. Mitchell, Bewley, Martin A, Dockrell, D. H., Read, Robert C, Tulone, Calogero, Francis, S.E., Robert C. Read, Dockrell David H., Bewley, Martin A., Martin A Bewley, Helen M. Marriott, Bewley, M. A., Dockrell, David, Bewley Martin A., Whyte, M. K. B., Guido Kroemer, Francis, Sheila E., Kroemer Guido   +63 more
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

1alpha,25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation [PDF]

, 2005
peer reviewed1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3), the activated vitamin D3 hormone, is a key regulator of calcium homeostasis and thereby indispensable for bone metabolism.
Frahm, Thomas, Ehrchen, Jan, Lengeling, Andreas, Helming, Laura, Geffers, Robert, Probst-Kepper, Michael, Schiebe, Stefanie, L. Helming, Böse, Jens, Balling, Rudi   +9 more
core   +1 more source