Results 101 to 110 of about 2,829,847 (276)

MACROPHAGE ACTIVATION SYNDROME IN PATIENTS WITH SYSTEMIC JUVENILE ARTHRITIS [PDF]

, 2014
Macrophage activation syndrome (MAS) is one of the histiocytic diseases developing from cells of a macrophage series, hemophagocytic lymphohis- tiocytosis (HLH). Rheumatic diseases have been demonstrated to be often associated with the development of SAM,
S. R. Rodionovskaya, I. P. Nikishina
core   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

A Case of Sarcoidosis with Atypical Presentation

Ahi Evran Medical Journal
Sarcoidosis is a multisystemic disease characterized by non-caseating granulomas of unknown etiology. While pulmonary manifestations are present in 90% of cases, extrapulmonary sarcoidosis cases are rare and diagnosis is often challenging due to atypical
Duygu Acer, Mehmet Veysel Coşkun, Selma Karaahmetoğlu, Ali Can Kurtipek   +3 more
doaj   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Macrophage Activation Syndrome in MIS-C

Pediatrics
BACKGROUND Multisystem inflammatory syndrome (MIS-C) represents a diagnostic challenge because of its overlap with Kawasaki disease, Kawasaki disease shock syndrome, and toxic shock syndrome. Macrophage activation syndrome (MAS) is a frequently fatal complication of various pediatric inflammatory disorders and has ...
Luisa Berenise, Gámez-González, Chiharu, Murata, Jimena, García-Silva, Rolando, Ulloa-Gutierrez, Martha, Márquez-Aguirre, Itzel, Ríos-Olivares, Enrique, Faugier-Fuentes, Jesús A, Domínguez-Rojas, Adriana, Yock-Corrales, Martha I, Álvarez-Olmos, Jaime, Fernández-Sarmiento, Mónica, Velasquez-Méndez, Gabriela, Ivankovich-Escoto, Adriana H, Tremoulet, Marco A, Yamazaki-Nakashimada   +14 more
openaire   +3 more sources

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis

European Medical Journal Allergy & Immunology, 2017
One of the complications of systemic juvenile idiopathic arthritis (SJIA) is macrophage activation syndrome (MAS), which may be considered as a form of secondary haemophagocytic lymphohistiocytosis.
Zhi-qiang Tu, Wei-qi Zhang
doaj  

A clinical analysis of hemophagocytic syndrome secondary to autoimmune diseases

The Turkish Journal of Gastroenterology, 2023
Objectives: This study aimed to analyze the differences of etiologies and clinical features between patients with autoimmune-associated hemophagocytic syndrome (AAHS) and those with other underlying diseases of hemophagocytic syndrome (HPS). Patients
Yang Liu, Qian Li, Yazhen Su, Guozhu Che, Ying Liu, Pengyan Qiao, Sumiao Liu, Ke Xu   +7 more
doaj  

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Macrophage activation syndrome in an inadequately treated patient with systemic onset juvenile idiopathic arthritis

, 2014
Macrophage activation syndrome is a rare and potentially life threatening complication of childhood rheumatic disorders. It is described most commonly with systemic onset juvenile idiopathic arthritis (soJIA).
Juneja M, Jain R, Mishra D
core