Results 101 to 110 of about 116,710 (303)

Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

Nature Communications, 2019
Stat6 promotes M2 macrophage polarization. Here the authors characterize Trim24-CBP-Stat6 circuit regulating M2 macrophage polarization via Stat6 acetylation, and show it contributes to pro-tumorigenic macrophage activity in mice.
Tao Yu, Shucheng Gan, Qingchen Zhu, Dongfang Dai, Ni Li, Hui Wang, Xiaosong Chen, Dan Hou, Yan Wang, Qiang Pan, Jing Xu, Xingli Zhang, Junli Liu, Siyu Pei, Chao Peng, Ping Wu, Simona Romano, Chaoming Mao, Mingzhu Huang, Xiaodong Zhu, Kunwei Shen, Jun Qin, Yichuan Xiao   +22 more
doaj   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Electroacupuncture Regulates Macrophage Polarization to Alleviate the Neuropathic Pain Induced by Spared Nerve Injury [PDF]

Guangxia Shi, Xiaowan Hao, Jian-Feng Tu, Wen Chen, Yiming Fu, Xin Ma, Cunzhi Liu, Hongping Li International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing ...
Li H, Chen W, Ma X, Shi G, Fu Y, Hao X, Liu C, Tu JF   +7 more
core   +1 more source

The magnesium-doped CSH/BCP promotes alveolar bone regeneration by mediating M2 macrophage polarization via miR-21–5p/Smad2 axis [PDF]

The repair of alveolar bone defects is a complex biological process that involves the interplay between implant materials, bone marrow mesenchymal stem cells (BMSCs), and the immune cells present in the surrounding area.
Liu, Y, Yan, T, Xu, J, Ye, Q, Sun, S, Zhou, J, Zhang, L, Liu, C, Zhang, Y, He, Y   +9 more
core   +1 more source

Mechanisms and Therapeutic Strategies of Macrophage Polarization in Intervertebral Disc Degeneration

JOR Spine
Background Intervertebral disc degeneration (IVDD) is a leading cause of low back pain (LBP), contributing significantly to global disability and productivity loss. Its pathogenesis involves complex processes, including inflammation, cellular senescence,
Kaiyuan Zheng, Siyu Wang, Meng Deng, Yaomin Luo, Wen Li, Lianlin Zeng, Yinxu Wang   +6 more
doaj   +1 more source

HOF‐Stabilized Apple EV Nanocargo in an NIR‐Responsive Hydrogel Enables On‐Demand Therapeutic Modulation for Transdermal Deep‐Joint Osteoarthritis Therapy

Advanced Healthcare Materials, EarlyView.
An NIR‐responsive transdermal hydrogel integrating apple EV nanocargo, berberine, piperine, HOFs, and graphene oxide enables localized osteoarthritis modulation. The platform supports enhanced transdermal delivery together with mild hyperthermia‐associated and redox‐related responses, leading to reduced inflammation and oxidative stress, improved ...
Yu‐Wen Tseng, Pei‐Wei Weng, Hsien‐Tsung Lu, Jiunn‐Horng Kang, Lekha Rethi, Lekshmi Rethi, Yan‐Ting Chen, Hieu Trung Nguyen, Yao‐Tung Tsai, Andrew E.‐Y. Chuang   +9 more
wiley   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Macrophage Polarization Favors Epithelial Repair During Acute Respiratory Distress Syndrome* [PDF]

, 2018
International audienceObjectives: Alveolar macrophage polarization and role on alveolar repair during human acute respiratory distress syndrome remain unclear.
Crestani, Bruno, Laschet, Jamila, Arnaud A. Mailleux, Marc Garnier, Bruno Crestani, Neuville, Mathilde, Véronique Leçon, Monique Dehoux, Christophe Quesnel, Grégoire Trebbia, Tanaka, Sébastien, Dehoux, Monique, Margarita Hurtado-Nedelec, Gibelin, Aude, Garnier, Marc, Quesnel, Christophe, Aude Gibelin, Leçon, Véronique, Sébastien Tanaka, Mailleux, Arnaud, A, Hurtado-Nedelec, Margarita, Jamila Laschet, Mathilde Neuville, Trebbia, Grégoire   +23 more
core   +1 more source

CD204 regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following intracerebral hemorrhage

Scientific Reports
Intracerebral hemorrhage (ICH) is a main cause of death and disability worldwide. Microglial/macrophage activation and neuroinflammation are key events following ICH, but the molecular mechanisms of mediator regulatory function are not well understood ...
Wujie Shi, Xu Li, Jing Meng, Min Li, Hanhai Zeng, Jing Cai   +5 more
doaj   +1 more source

Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: Molecular mechanisms and targeted therapies

Pharmacological Research
Atherosclerosis, a multifactorial progressive inflammatory disease, is the common pathology underlying cardiovascular and cerebrovascular diseases. The macrophage plasticity is involved in the pathogenesis of atherosclerosis.
Pinglian Yang, Xiaoling Rong, Zhechang Gao, Jiaojiao Wang, Zhiping Liu   +4 more
doaj   +1 more source