Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis. [PDF]
, 2017 Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy.
Castegna, Alessandra +12 more
core +11 more sources
Scientific ReportsSeveral studies have demonstrated that exosomes (Exos) are involved in the regulation of macrophage polarization and osteoclast differentiation. However, the characteristics as well as roles of exosomes from human periodontal ligament cells (hPDLCs-Exos)
Xinyi Bai +7 more
doaj +1 more source
Phagosome maturation in polarized macrophages [PDF]
Journal of Leukocyte Biology, 2014 ABSTRACTMacrophages are capable of assuming distinct, meta-stable, functional phenotypes in response to environmental cues—a process referred to as macrophage polarization. The identity and plasticity of polarized macrophage subsets as well as their functions in the maintenance of homeostasis and the progression of various pathologies have become areas
openaire +2 more sources
Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2 [PDF]
, 2014 SummaryAlthough imbalances in gut microbiota composition, or “dysbiosis,” are associated with many diseases, the effects of gut dysbiosis on host systemic physiology are less well characterized.
Kim, Yun-Gi +5 more
core +1 more source
Transcriptomic Profiles of Monocyte-Derived Macrophages in Response to Escherichia coli is Associated with the Host Genetics. [PDF]
, 2020 Reactive Nitrogen Species (RNS) are a group of bactericidal molecules produced by macrophages in response to pathogens in a process called oxidative burst.
Cánovas, Angela +5 more
core
Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages [PDF]
, 2018 open11noSeveral studies suggest that curcumin and related compounds possess antioxidant and anti-inflammatory properties including modulation of lipopolysaccharide- (LPS-) mediated signalling in macrophage cell models. We here investigated the effects of
core +1 more source
Feline coronaviruses associated with feline infectious peritonitis have modifications to spike protein activation sites at two discrete positions [PDF]
arXiv, 2014 Feline infectious peritonitis (FIP) is associated with mutations in the feline coronavirus (FCoV) genome that are thought to convert the subclinical feline enteric coronavirus (FECV) into the lethal feline infectious peritonitis virus (FIPV). A key feature of FIPV, not shared with FECV, is the productive infection of macrophages. Therefore mutations in
arxiv
Effects of acute alcohol treatment on macrophage polarization [PDF]
Alcohol is an underestimated toxicant, and binge drinking is increasing rapidly. Macrophages are important immune cells characterized by heterogeneity and can be polarized into pro-inflammatory and anti-inflammatory phenotypes.To elucidate the effects of
Liu, Liyuan
core +1 more source
Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages [PDF]
, 2010 Background Interleukin-33 is a member of the IL-1 cytokine family whose functions are mediated and modulated by the ST2 receptor. IL-33-ST2 expression and interactions have been explored in mouse macrophages but little is known about the effect of IL-33 ...
Das, Anuk +7 more
core +5 more sources
Estimating the number of tissue resident macrophages [PDF]
arXiv, 2016 I provide a simple estimation for the number of macrophages in a tissue, arising from the hypothesis that they should keep infections below a certain threshold, above which neutrophils are recruited from blood circulation. The estimation reads Nm=a Ncel^{\alpha}/Nmax, where a is a numerical coefficient, the exponent {\alpha} is near 2/3, and Nmax is ...
arxiv