Results 141 to 150 of about 538,375 (255)

OGT-mediated O-GlcNAcylation regulates macrophage polarization in heart failure via targeting IRF1

BMC Cardiovascular Disorders
Background Heart failure (HF) is a syndrome with complex etiology and high mortality in the world. Macrophage-related inflammation is involved in HF development.
Guoqiang Jing, Yuhong Ma
doaj   +1 more source

Imrecoxib attenuates osteoarthritis by modulating synovial macrophage polarization through inactivating COX-2/PGE2 signaling pathway

Frontiers in Bioengineering and Biotechnology
IntroductionAlthough biomaterials strategies have been regarded as a promising approach for the treatment of osteoarthritis (OA), identifying novel drugs to be delivered for modulate macrophage polarization is still unclear.
Peng Peng, Peng Peng, Peng Peng, Wanling Zheng, Yuchen Liu, Jingyuan Huang, Bin Zhang, Jiawei Shen, Jiangang Cao   +8 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Interplay of autophagy and Th1/Th2-mediated macrophage polarization in host-pathogen dynamics

Frontiers in Cellular and Infection Microbiology
Autophagy, host immune responses, and macrophage polarization form a tightly regulated network. This network significantly influences the outcome of intracellular pathogenic infections. Autophagy acts as a critical cellular defense mechanism. It degrades
Gaurav Shoeran, Namrata Anand
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Polarization: Concepts, Measurement, Estimation [PDF]

The purpose of this paper is two-fold. First, we develop the measurement theory of polarization for the case in which asset distributions can be described using density functions.
Esteban, Joan, Ray, Debraj, Duclos, Jean-Yves   +2 more
core  

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Histone lactylation-induced GLI3 activation drives macrophage M1 polarization and exosomal SERPINE1 release in abdominal aortic aneurysm progression

Cell Death Discovery
M1 macrophages promote the progression of abdominal aortic aneurysm (AAA). Lactate-mediated histone lactylation modification regulates macrophage M1 polarization.
Kai Yuan, Junjian Liu, Guanghui Chen, Peng Wang, Liang Wei   +4 more
doaj   +1 more source

HMGB1 Modulates Macrophage Metabolism and Polarization in Ulcerative Colitis by Inhibiting Cpt1a Expression

Frontiers in Bioscience-Landmark
Background: Macrophage polarization is involved in the development of ulcerative colitis (UC). This study investigated the mechanism by which high mobility group box-1 protein (HMGB1) regulates macrophage polarization through metabolic
Fenfen Wang, Linfei Luo, Zhengqiang Wu, Lijun Wan, Fan Li, Zhili Wen   +5 more
doaj   +1 more source

Azithromycin Augments Bacterial Uptake and Anti-Inflammatory Macrophage Polarization in Cystic Fibrosis

Background: Azithromycin (AZM) is widely being used for treating patients with cystic fibrosis (pwCF) following clinical trials demonstrating improved lung function and fewer incidents of pulmonary exacerba-tions.
Richard M. Lucas, Jennifer L. Stow, Tuladhar, Neeraj, Stow, Jennifer L, Begum, Nelufa, Emmanuelle Fantino, Nelufa Begum, Peter D. Sly, Tarique, Abdullah A, Neeraj Tuladhar, Kelk, Dean, Sly, Peter D, Fantino, Emmanuelle, Bell, Scott C, Luo, Lin, Wainwright, Claire E, Lin Luo, Dean Kelk, Claire E. Wainwright, Lucas, Richard M, Abdullah A. Tarique, Scott C. Bell   +21 more
core   +1 more source