Results 141 to 150 of about 116,710 (303)

Leveraging a comprehensive unbiased RNAseq database to characterize human monocyte-derived macrophage gene expression profiles within commonly employed in vitro polarization methods

Scientific Reports
Macrophages are pivotal innate immune cells which exhibit high phenotypic plasticity and can exist in different polarization states dependent on exposure to external stimuli.
Timothy Smyth, Alexis Payton, Elise Hickman, Julia E. Rager, Ilona Jaspers   +4 more
doaj   +1 more source

Maskless Fabrication of PLA‐Based Neural Arrays for CNS Recording and Stimulation

Advanced Materials Interfaces, EarlyView.
Biodegradable neural interfaces enable bidirectional communication with the CNS. Through electrochemical characterization, ageing tests with impedance monitoring, and in vivo validation, we assess the performance of PLA‐based epicortical and spinal implants.
Anna De Salvo, Federica Velluto, Ilenia Sergi, Michele Di Lauro, Verónica Barranco‐Maresca, Elena Alonso‐Calviño, Yasmina Hernández‐Martín, Juan Aguilar, Juliana M. Rosa, María C. Serrano, Carolina Giulia Ferroni, Federico Rondelli, Elisa López‐Dolado, Luciano Fadiga, Fabio Biscarini   +14 more
wiley   +1 more source

Extrusion Bioprinting for Wound Healing: Innovations in Functionalized Bioinks and Bioprinting Technology

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le, Anh Tuan Trong Tran, Ammara Waheed, Tran Thanh Tung, Dusan Losic   +4 more
wiley   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Generierung von Sphingosin-1-Phosphat durch apoptotische Zellen und dessen Einfluss auf die Polarisierung von Makrophagen während der Tumorentwicklung [PDF]

, 2008
The removal of apoptotic cells (AC) can be regarded as an integral component of the program to terminate inflammation. Clearance of AC by professional phagocytes such as macrophages induces an anti-inflammatory phenotype in the latter ones.
Weigert, Andreas
core  

OGT-mediated O-GlcNAcylation regulates macrophage polarization in heart failure via targeting IRF1

BMC Cardiovascular Disorders
Background Heart failure (HF) is a syndrome with complex etiology and high mortality in the world. Macrophage-related inflammation is involved in HF development.
Guoqiang Jing, Yuhong Ma
doaj   +1 more source

Imrecoxib attenuates osteoarthritis by modulating synovial macrophage polarization through inactivating COX-2/PGE2 signaling pathway

Frontiers in Bioengineering and Biotechnology
IntroductionAlthough biomaterials strategies have been regarded as a promising approach for the treatment of osteoarthritis (OA), identifying novel drugs to be delivered for modulate macrophage polarization is still unclear.
Peng Peng, Peng Peng, Peng Peng, Wanling Zheng, Yuchen Liu, Jingyuan Huang, Bin Zhang, Jiawei Shen, Jiangang Cao   +8 more
doaj   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Interplay of autophagy and Th1/Th2-mediated macrophage polarization in host-pathogen dynamics

Frontiers in Cellular and Infection Microbiology
Autophagy, host immune responses, and macrophage polarization form a tightly regulated network. This network significantly influences the outcome of intracellular pathogenic infections. Autophagy acts as a critical cellular defense mechanism. It degrades
Gaurav Shoeran, Namrata Anand
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source