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Macrophage polarization in pathology
Cellular and Molecular Life Sciences, 2015Macrophages are cells of the innate immunity constituting the mononuclear phagocyte system and endowed with remarkable different roles essential for defense mechanisms, development of tissues, and homeostasis. They derive from hematopoietic precursors and since the early steps of fetal life populate peripheral tissues, a process continuing throughout ...
SICA, Antonio +3 more
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Serine metabolism in macrophage polarization
Inflammation Research, 2023Emerging studies have revealed that macrophages possess different dependences on the uptake, synthesis, and metabolism of serine for their activation and functionalization, necessitating our insight into how serine availability and utilization impact macrophage activation and inflammatory responses.This article summarizes the reports published ...
Xinqiong, Huang +3 more
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Current Opinion in Lipidology, 2014
The first functions of macrophages to be identified by Metchnikoff were phagocytosis and microbial killing. Although these are important features, macrophages are functionally very complex and involved in virtually all aspects of life, from immunity and host defense, to homeostasis, tissue repair and development.
Jan, Van den Bossche +3 more
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The first functions of macrophages to be identified by Metchnikoff were phagocytosis and microbial killing. Although these are important features, macrophages are functionally very complex and involved in virtually all aspects of life, from immunity and host defense, to homeostasis, tissue repair and development.
Jan, Van den Bossche +3 more
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Polarized Activation of Macrophages
2014Macrophages are mononuclear phagocytes which play important roles in many aspects of immunity, tissue repair and metabolism. Plasticity is a key feature of these cells and consists in the capability to modulate their phenotypic and functional aspects under distinct stimuli derived from the microenvironment. A number of transcription factors, epigenetic
Galdiero, M. R. +2 more
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Orchestration of macrophage polarization
Blood, 2009Abstract In this issue of Blood, Ishii and colleagues shed new, fresh light on molecular mechanisms underlying one form of macrophage activation.
A. Mantovani, M. Locati
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Annual Review of Physiology, 2017
Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and the normal tissue environment.
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Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and the normal tissue environment.
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Macrophage polarization in placenta accreta and macrophage‐trophoblast interactions
American Journal of Reproductive Immunology, 2022AbstractProblemPlacenta accreta (PA) is defined by an abnormal invasion of placental trophoblasts into the myometrium, which can lead to serious postpartum complications. Macrophages play an important role in the regulation of trophoblast function.
Jia‐hui Che +3 more
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Macrophage polarization and bacterial infections
Current Opinion in Infectious Diseases, 2011Macrophages are the first line of defense against pathogens, and the mode of their activation will determine the success or failure of the host response to pathogen aggression. Based on limited numbers of markers, activated macrophages can be classified as classically activated (M1) macrophages that support microbicidal activity or alternatively ...
Jean-Louis, Mège +2 more
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Macrophage polarization in tumour progression
Seminars in Cancer Biology, 2008Macrophages are a fundamental part of the innate defense mechanisms, which can promote specific immunity by inducing T cell recruitment and activation. Despite this, their presence within the tumour microenvironment has been associated with enhanced tumour progression and shown to promote cancer cell growth and spread, angiogenesis and ...
SICA, Antonio +9 more
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Macrophage polarization following chitosan implantation
Biomaterials, 2013Macrophages are a key cell in the host response to implants and can be polarized into different phenotypes capable of inducing both detrimental and beneficial outcomes in tissue repair and remodeling, being important in tissue engineering and regenerative medicine.
Daniela P, Vasconcelos +6 more
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