Results 281 to 290 of about 1,598,228 (339)

A streamlined and comprehensive protocol for the generation and multi-omic analysis of human monocyte-derived macrophages. [PDF]

BMC Biotechnol
Palmer OG, Perreard L, Kolling Iv FW, Pioli PA, Goods BA.   +4 more
europepmc   +1 more source

Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions

Advanced Healthcare Materials, EarlyView.
Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi, Lisa A. Krattiger, Magdalini Kanari, Mira A. Jacobs, Lukas O. Moser, Mark W. Tibbitt, Cornelia Halin, Martin Ehrbar   +7 more
wiley   +1 more source

Brucella abortus infection exploits ZDHHC3-mediated STAT3 palmitoylation to regulate host responses and promote persistence. [PDF]

Vet Res
Liu X, Yu J, Chen Y, Liu H, Liu N, Peng Q.   +5 more
europepmc   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

Cytochemical Characterization for Macrophages Engulf Cholesterol Crystals and Myeloperoxidase in Neutrophil Extracellular Traps (NETs) Sampled From Disrupted Aortic Plaques. [PDF]

J Histochem Cytochem
Iwa N, Noda H, Yutani C, Komatsu S, Takahashi S, Takewa M, Ohara T, Kodama K.   +7 more
europepmc   +1 more source

Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering

Advanced Healthcare Materials, EarlyView.
This study presents an advanced in vitro model of the vascular hematopoietic stem cell niche using self‐assembled fibrinogen nanofibers, mimicking the basement membrane in bone marrow (BM) sinusoids. The model supports the coculture of microvascular endothelial cells, stromal cells, and hematopoietic stem and progenitor cells, providing insights into ...
Sophia Lena Meermeyer, Arundhati Joshi, Constantin von Kaisenberg, Dorothea Brüggemann, Cornelia Lee‐Thedieck   +4 more
wiley   +1 more source

Targeting IQGAP3 skews macrophages polarization towards M1 phenotype and promotes antitumor immune response. [PDF]

Cell Mol Life Sci
Li X, An X, Zhang Y, Zhang S, Zeng L, Shi J, Wu S, Wang Y, Xu Y, Lv X, Yang S, Yuan B.   +11 more
europepmc   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

A microbiota-dependent bile acid reprograms alveolar macrophages to control lung inflammation. [PDF]

Signal Transduct Target Ther
Wolska M, Rodríguez-Viso P, Świątkowska A, Bulanda E, Wypych TP.   +4 more
europepmc   +1 more source