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Macroprolactinemia: Clinical Significance and Characterization of the Condition.
Acta Clinica Belgica, 2005 The purpose of this study was to characterize the clinical picture of macroprolactinemic patients and to further assess whether macroprolactinemia was part of an auto-immune syndrome. Eighty-two hyperprolactinemic (serum PRL > 1000 mU/l) patients were investigated and the PEG precipitation test identified 14 patients with macroprolactinemia (bb PRL ...
Theunissen, C. +5 more
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Macroprolactinemia Revisited: A Study on 106 Patients. [PDF]
Journal of Clinical Endocrinology and Metabolism, 2002 The predominance of high molecular weight PRL, or macroprolactinemia, has long been known in hyperprolactinemic patients with maintained fertility. Among 1,106 consecutive patients investigated for hyperprolactinemia in our center over a 10-yr period, serum PRL chromatography was performed in 368 cases because of discordant clinical, biological, or ...
Thierry Brue +2 more
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Prevalence and reproductive manifestations of macroprolactinemia
Endocrine, 2018Macroprolactinemia is characterized by predominance of macroprolactin molecules in circulation and generally has extra-pituitary origin. Macroprolactin is viewed as biologically inactive, therefore asymptomatic, and thus may not require any treatment or prolonged follow-up.
Amanpreet Kaur, Kalsi +4 more
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International Journal of Environmental Research and Public Health, 2020 Hyperprolactinemia (hPRL) often poses a diagnostic dilemma due to the presence of macroprolactin. Understanding the prevalence of macroprolactinemia (mPRL) has an important implication in managing patients with hPRL.
Noor Azlin Azraini Che Soh +2 more
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Macroprolactinemia in hyperprolactinemic infertile women
Endocrine, 2013Hyperprolactinemia occurs in 15-20 % of women with menstrual disturbances and 30-40 % of infertile women and it can adversely affect the fertility. High molecular weight prolactin (macroprolactin) has long been known in hyperprolactinemic fertile women.
Krithika, Thirunavakkarasu +7 more
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Macroprolactinemia: The Consequences of a Laboratory Pitfall
Endocrine, 2003The objective of this study was to assess the prevalence of macroprolactin, a macromolecule with reduced bioactivity, in hyperprolactinemic patients. Prolactin was measured before and after precipitation of macroprolactin by polyethylene glycol in 306 patients. Only patients with prolactin values >700 mIU/L (n = 270) entered the study.
Erzsébet, Toldy +6 more
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Hyperthyroidism, Hyperprolactinemia, and Macroprolactinemia
Annals of Internal Medicine, 1990Excerpt To the Editor:We read with interest the excellent review on thyrotropin-secreting pituitary adenomas by Gesundheit and colleagues (1).
Jacobo Wortsman, William B. Malarkey
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Macroprolactinemia in Childhood and Adolescence: A Cause of Asymptomatic Hyperprolactinemia
Hormone Research, 2000Asymptomatic hyperprolactinemias associated with altered proportions of molecular forms of circulating prolactin (PRL) have been reported in adults. The scarce references available in children and adolescents prompted us to report our experience in the evaluation and follow-up of patients with macroprolactinemia.
H L Fideleff
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Macroprolactinemia in a Patient with Infertility and Hyperprolactinemia
Southern Medical Journal, 2006A significant number of patients with hyperprolactinemia have macroprolactinemia, a condition characterized by the preponderance of big-big prolactin with normal levels of free prolactin. As macroprolactin does not have biologic activity, such patients do not require further investigations or treatment for hyperprolactinemia. The case of a patient with
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