Results 91 to 100 of about 160,800 (350)

Importance of Müller Cells

Beyoglu Eye Journal, 2020
Müller cells (MCs) are the most common glial cell found in the human retina. MCs have an important role in architectural and metabolic functions in the retina.
Sabiha Gungor Kobat, Burak Turgut
doaj   +1 more source

Recent Advancements in the Treatment of Age‐Related Macular Degeneration

Med Research, EarlyView.
ABSTRACT Age‐related macular degeneration (AMD) is a prevalent cause of visual impairment and blindness among the elderly. AMD can be categorized into two subtypes: “wet” and “dry.” Current treatments for wet AMD mainly involve anti‐vascular endothelial growth factor (VEGF) drugs, and there are three U.S.
Shan Liu, Danyang Lv, Junran Sun, Huixun Jia, Fang Zheng, Felipe Pereira, Siddharth Narendran, Zhenyu Dong, Haiyun Liu, Shunxiang Gao, Peirong Huang   +10 more
wiley   +1 more source

Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. [PDF]

, 2017
Age-related macular degeneration (AMD) ranks third among the leading causes of visual impairment with a blindness prevalence rate of 8.7%. Despite several treatment regimens, such as anti-angiogenic drugs, laser therapy, and vitamin supplementation ...
Chwa, Marilyn, Cohen, Pinchas, Kenney, M Cristina, Kuppermann, Baruch D, Lu, Stephanie, Nashine, Sonali, Nesburn, Anthony B   +6 more
core   +1 more source

Optic Disc Pallor in Parkinson's Disease: A UK Biobank Study

Movement Disorders, EarlyView.
Abstract Background Recent studies have suggested that retinal changes measured with optical coherence tomography are detectable in early Parkinson's disease (PD), highlighting the potential of ophthalmic biomarkers for diagnosis and monitoring. Objective We set out to investigate the relationship between optic disc pallor measured in fundoscopy images
Samuel Gibbon, David P. Breen, Thomas J. MacGillivray, UK Biobank Eye & Vision Consortium   +3 more
wiley   +1 more source

Current Advances in the Combination of Fatty Acids and Resveratrol to Fight Ocular Diseases

Molecular Nutrition &Food Research, EarlyView.
Graphical abstract illustrating the effects of Resvega administration on choroidal neovascularization and resveratrol metabolism in the retina. The diagram illustrates that oral administration of Resvega leads to a decrease in choroidal neovascularization.
Dominique Delmas, Maude Perus, Virginie Aires, François Hermetet   +3 more
wiley   +1 more source

Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular‐Related Complications

Molecular Nutrition &Food Research, EarlyView.
(Poly)phenols constitute a source of natural therapeutic molecules capable of targeting angiogenesis in different scenarios. This review summarizes the current evidence of the role of (poly)phenols in modulating angiogenesis. The reader can find a compilation of preclinical and human investigations describing pro‐ and anti‐angiogenic effects of these ...
María Ángeles Ávila‐Gálvez, Antonio Vico‐Padilla, Claus Schneider, Juan Carlos Espín, Antonio González‐Sarrías, Juan Antonio Giménez‐Bastida   +5 more
wiley   +1 more source

Progress in Aptamer Research and Future Applications

ChemistryOpen, EarlyView.
This paper mainly describes the screening method of aptamer, the screening difficulties and improvement methods of small molecule aptamer, and the application and treatment of aptamer. It explores the latest progress and application of aptamers, and summarises them, thus indicating some problems that still exist in this field.
Song Liu, Xiaolu Li, Huyang Gao, Jing Chen, Hongfeng Jiang   +4 more
wiley   +1 more source

The Relationship between Complements and Age-Related Macular Degeneration and Its Pathogenesis

Journal of Ophthalmology
Age-related macular degeneration is a retinal disease that causes permanent loss of central vision in people over the age of 65. Its pathogenesis may be related to mitochondrial dysfunction, inflammation, apoptosis, autophagy, complement, intestinal ...
Liyuan Chu, Chaoran Bi, Caiming Wang, Hongyan Zhou   +3 more
doaj   +1 more source

Comprehensive functional splicing analysis of non‐canonical CNGB3 variants using in vitro minigene splice assays

The Journal of Pathology, EarlyView.
Abstract Variants in the CNGB3 gene, encoding the B3‐subunit of the cone photoreceptor cyclic nucleotide gated channel, are a major cause of autosomal recessive achromatopsia, a rare inherited retinal disease. The mutation spectrum of achromatopsia‐associated CNGB3 variants comprises all types of mutations, including those that are straightforward to ...
Katharina Rawnsley, Nicole Weisschuh, Susanne Kohl, Peggy Reuter   +3 more
wiley   +1 more source

Multi-line Adaptive Perimetry (MAP): A New Procedure for Quantifying Visual Field Integrity for Rapid Assessment of Macular Diseases. [PDF]

, 2018
PurposeIn order to monitor visual defects associated with macular degeneration (MD), we present a new psychophysical assessment called multiline adaptive perimetry (MAP) that measures visual field integrity by simultaneously estimating regions associated
Biles, Mandy K, Davey, Pinakin G, Maniglia, Marcello, Seitz, Aaron R, Thurman, Steven M, Visscher, Kristina M   +5 more
core   +1 more source