Results 91 to 100 of about 511,582 (401)

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration

BMJ Open Ophthalmology, 2021
Age-related macular degeneration (AMD) is the most common eye disease in elderly patients, which could lead to irreversible vision loss and blindness. Increasing evidence indicates that amyloid β-peptide (Aβ) might be associated with the pathogenesis of ...
Jiantao Wang, Xinghuai Sun, Minwei Wang, Shiqi Su, Shaoyun Jiang   +4 more
doaj   +1 more source

Dysregulated metabolic pathways in age-related macular degeneration

Scientific Reports, 2020
Age-related macular degeneration is a major cause of vision impairment in the Western world among people of 55 years and older. Recently we have shown that autophagy is dysfunctional in the retinal pigment epithelium (RPE) of the AMD donor eyes (AMD RPE).
Meng Zhang, Nisi Jiang, Yi Chu, O. Postnikova, R. Varghese, A. Horvath, A. Cheema, N. Golestaneh   +7 more
semanticscholar   +1 more source

A variance components factor model for genetic association studies: a Bayesian analysis.

, 2010
Studies of gene-trait associations for complex diseases often involve multiple traits that may vary by genotype groups or patterns. Such traits are usually manifestations of lower-dimensional latent factors or disease syndromes.
Nonyane, BAS, Whittaker, JC
core   +1 more source

Evolution of Ocular Organ‐On‐Chip Systems for Disease Modelling and Drug Testing: Where are We Now?

Advanced Therapeutics, EarlyView.
The rise in ophthalmic diseases due to aging, screen use, and environmental factors has driven demand for better ocular models. Traditional systems fall short, encouraging the development of organ‐on‐chip devices. These microfluidic platforms replicate eye tissue architecture, enable drug screening, and simulate ocular diseases.
Sara Trujillo
wiley   +1 more source

Avaliação dos efeitos adversos desencadeados pelo uso de difosfato de cloroquina, com ênfase na retinotoxicidade, em 350 doentes com lúpus eritematoso Evaluation of adverse events triggered by the use of chloroquine diphosphate, emphasis on retina toxicity, in 350 patients with lupus erythematosus

Anais Brasileiros de Dermatologia, 2005
FUNDAMENTOS: A ocorrência de retinopatia pela cloroquina vem diminuindo em todo o mundo, com poucos estudos brasileiros sobre o problema. OBJETIVOS: Compreender melhor a fisiopatologia das reações tipo 1.
Maria Raquel Nogueira C. Ponchet, Maria Apparecida C. Vilela, Karen Krist Suni Sinahara, Patrícia de Freitas Dotto   +3 more
doaj   +1 more source

Mechanisms of Macular Degeneration

Vision Research, 2010
The 12th Annual Vision Research Conference, ‘‘Mechanisms of Macular Degeneration” was held at the Convention Center at Ft. Lauderdale, Florida, May 1–2, 2009. The meeting reviewed the latest developments in the genetics of AMD, and focused on animal models that closely mimic early or late onset human macular diseases.
Greg Hageman, Theodore G. Wensel, Donald J. Zack, Samuel Wu, Wolfgang Baehr   +4 more
openaire   +2 more sources

A Method of Drusen Measurement Based on the Geometry of Fundus Reflectance [PDF]

, 2003
BACKGROUND: The hallmarks of age-related macular degeneration, the leading cause of blindness in the developed world, are the subretinal deposits known as drusen.
A Abdelsalam, AC Bird, Caroline CW Klaver, CC Klaver, D Schweitzer, DM Snodderly, DS Shin, E Peli, FG Holz, Group The Choroidal Neovascularization Pr, HL Little, IC Frennesson, Irene Barbazetto, J Sigelman, J van de Kraats, Jackie K Chan, Janet R Sparrow, JC Russ, JJ Weiter, JM Bland, JN Kirkpatrick, K Rapantzikos, L Leistritz, M Sebag, MH Goldbaum, MS Figueroa, MS Figueroa, NM Bressler, NM Bressler, R Klein, R Theodore Smith, RA Bone, RL Radius, RT Smith, RT Smith, RW Knighton, SB Bressler, SB Bressler, Takayuki Nagasaki, TE Ogden, TE Ogden, WE Smiddy, WH Morgan   +42 more
core   +4 more sources

Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer

Advanced Science, EarlyView.
This review compares clinical outcomes, translational progress, and global funding trends across cancer phototherapies—photodynamic, photothermal, and photoimmunotherapy—and conventional immunotherapy. It highlights differences in treatment efficacy, clinical trial status, financial investment, and regulatory challenges, providing a comprehensive ...
Deepak S. Chauhan, Kun Shao, Roopa Hebbandi Nanjundappa, Daniel‐Jiajun Yu, Marianne Stanford, Huile Gao, Channakeshava Sokke Umeshappa   +6 more
wiley   +1 more source

Macular pigment and age related macular degeneration [PDF]

British Journal of Ophthalmology, 1999
The yellow coloration of the macula lutea is attributable to the presence of macular pigment in the axons of its photoreceptors.1 In the 1980s several investigators demonstrated that macular pigment consists of the xanthophyll isomers, lutein and zeaxanthin.2 3 Although the role of the macular pigment remains uncertain, several functions have been ...
Beatty, S., Boulton, M., Henson, D., Koh, H. H., Murray, I. J.   +4 more
openaire   +4 more sources