Results 81 to 90 of about 285,624 (259)

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Association of drusen deposition with choroidal intercapillary pillars in the aging human eye [PDF]

, 2004
PURPOSE. To determine the pattern of drusen accumulation with age and to investigate the initial sites of deposition and their relationship to choroidal capillaries in human donor eyes from the eye bank of Moorfields Eye Hospital.METHODS.
Al Hosaini, H, Bird, AC, Tufail, A, Jeffery, G, Luthert, P, Lengyel, I   +5 more
core  

Competitive SELEX Strategy for High‐Affinity Aptamer Isolation and Enhanced Biosensing

Small, EarlyView.
A novel competitive SELEX strategy was developed to isolate high‐affinity aptamers by using a lower‐affinity competitor during the selection process. This approach enabled the identification of an aptamer with exceptional binding affinity, significantly improving target detection sensitivity.
Jiuxing Li, Jiaxuan Xiao, Jimmy Gu, Zhen Zhang, Yingfu Li   +4 more
wiley   +1 more source

Physical activity and the risk of cataract and age-related macular degeneration: a systematic review and meta-analysis of cohort studies

BMC Ophthalmology
Background Physical activity has been associated with a lower risk of cataract and age-related macular degeneration in some studies; however, the available evidence has not been fully consistent.
Dagfinn Aune, Ahmad Jayedi, Asma Kazemi, Sepideh Soltani, Fatemeh Rezaei, Michael F. Leitzmann   +5 more
doaj   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Multiple Imputation and Random Forests (MIRF) for Unobservable, High-Dimensional Data [PDF]

, 2007
Understanding the genetic underpinnings to complex diseases requires consideration of sophisticated analytical methods designed to uncover intricate associations across multiple predictor variables.
Nonyane, BAS, Foulkes, AS
core   +2 more sources

The Relationship between Complements and Age-Related Macular Degeneration and Its Pathogenesis

Journal of Ophthalmology
Age-related macular degeneration is a retinal disease that causes permanent loss of central vision in people over the age of 65. Its pathogenesis may be related to mitochondrial dysfunction, inflammation, apoptosis, autophagy, complement, intestinal ...
Liyuan Chu, Chaoran Bi, Caiming Wang, Hongyan Zhou   +3 more
doaj   +1 more source

Intravitreal Ranibizumab Therapy in Wet Type Macular Degeneration

, 2014
Objectives: To evaluate the efficacy and safety of intravitreal ranibizumab treatment in all types of choroidal neovascularization that developed secondary to age-related macular degeneration.
Hasan Altınkaynak, Ahmet Taylan Yazıcı, Kemal Yüksel, Can Kocasaraç, Leyla Hazar, Hüseyin Dündar   +5 more
core   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration - the potential sources and molecular cues for their recruitment and activation

EBioMedicine, 2018
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in developed countries. Neovascular AMD (nAMD) accounts for 90% of AMD-related vision loss.
Karis Little, Jacey H. Ma, Nan Yang, Mei Chen, Heping Xu   +4 more
doaj   +1 more source