Results 91 to 100 of about 340,047 (304)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Physical activity and the risk of cataract and age-related macular degeneration: a systematic review and meta-analysis of cohort studies

BMC Ophthalmology
Background Physical activity has been associated with a lower risk of cataract and age-related macular degeneration in some studies; however, the available evidence has not been fully consistent.
Dagfinn Aune, Ahmad Jayedi, Asma Kazemi, Sepideh Soltani, Fatemeh Rezaei, Michael F. Leitzmann   +5 more
doaj   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration - the potential sources and molecular cues for their recruitment and activation

EBioMedicine, 2018
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in developed countries. Neovascular AMD (nAMD) accounts for 90% of AMD-related vision loss.
Karis Little, Jacey H. Ma, Nan Yang, Mei Chen, Heping Xu   +4 more
doaj   +1 more source

Assessment of visual functions of patients with senile macular degeneration

, 1981
Senile Macular Degeneration (SMD) can be detected and the progression of the disease monitored by the assessment and measurement of a number of visual functions. Considerable research has been conducted during the past ten years, much of it in Australia,
Lovie-Kitchin, Jan E.
core  

Age-Related Macular Degeneration: Classification and Pathogenesis

, 2014
Age-related macular degeneration (AMD) was first described in 1885 by Otto Haab as a disease in patients above 50 years of age with progressive retinal pigment epithelial and atrophic degenerations of the macula reducing the central visual acuity.
İmren Akkoyun
core   +1 more source

Competitive SELEX Strategy for High‐Affinity Aptamer Isolation and Enhanced Biosensing

Small, EarlyView.
A novel competitive SELEX strategy was developed to isolate high‐affinity aptamers by using a lower‐affinity competitor during the selection process. This approach enabled the identification of an aptamer with exceptional binding affinity, significantly improving target detection sensitivity.
Jiuxing Li, Jiaxuan Xiao, Jimmy Gu, Zhen Zhang, Yingfu Li   +4 more
wiley   +1 more source

Evaluation of an oral telomerase activator for early age-related macular degeneration - a pilot study

Clinical Ophthalmology, 2016
Coad Thomas Dow,1,2 Calvin B Harley3 1McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA; 2Chippewa Valley Eye Clinic, Eau Claire, Wisconsin, WI, USA; 3Independent Telomere Biology Consultant, Murphys, CA, USA Purpose ...
Dow CT, Harley CB
doaj  

Intravitreal Ranibizumab Therapy in Wet Type Macular Degeneration

, 2014
Objectives: To evaluate the efficacy and safety of intravitreal ranibizumab treatment in all types of choroidal neovascularization that developed secondary to age-related macular degeneration.
Hasan Altınkaynak, Ahmet Taylan Yazıcı, Kemal Yüksel, Can Kocasaraç, Leyla Hazar, Hüseyin Dündar   +5 more
core   +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source