Results 101 to 110 of about 511,582 (401)

Association of drusen deposition with choroidal intercapillary pillars in the aging human eye [PDF]

, 2004
PURPOSE. To determine the pattern of drusen accumulation with age and to investigate the initial sites of deposition and their relationship to choroidal capillaries in human donor eyes from the eye bank of Moorfields Eye Hospital.METHODS.
Al Hosaini, H, Bird, AC, Jeffery, G, Lengyel, I, Luthert, P, Tufail, A   +5 more
core   +1 more source

Red Blood Cell Membrane Lipidomics: Potential Biomarkers Detecting Method for Plasma Volume Overload and Major Adverse Cardiovascular Events in Chronic Heart Failure Patients

Advanced Science, EarlyView.
A novel RBC indicator, ESI, is better than the traditional RBC indicators and is associated with CHF prevalence and in‐hospital death. RBC membrane lipidomics, Cer 18:0;O2/16:0, and LPE 18:0, are associated with plasma volume overload and MACE in CHF patients, but these plasma lipids could not.
Lin Zhang, Xiangqin Ou, Jingyi Lin, Xiaofei Luo, Jiashun Zhou, Xingyue Zhou, Peihua Zhao, Li Liu, Ziran Zhao, Ying Zhou, Guanwei Fan, Lifeng Han, Xiumei Gao   +12 more
wiley   +1 more source

Real world pharmacovigilance assessment of drug related macular degeneration risks

Scientific Reports
Macular degeneration is a leading cause of irreversible vision loss, significantly impacting quality of life. To enhance clinical practice and reduce the risk of drug-related macular degeneration, we analyzed drug-related trends using real-world data ...
Xiaodong Chen, Shinan Wu, Shaopan Wang, Chaofeng Yu, Zihan Guo, Shiya Huang, Peixin Cai, Yanliang Miao, Shiying Li, Qian Chen   +9 more
doaj   +1 more source

Safety and Efficacy of Different Doses and Regimens of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration

JAMA ophthalmology, 2020
This phase 2 randomized clinical trial assesses the efficacy and safety of different doses and regimens of faricimab vs ranibizumab in patients with neovascular age-related macular degeneration.
J. Sahni, P. Dugel, Sunil S. Patel, M. Chittum, B. Berger, M. del Valle Rubido, S. Sadikhov, P. Szczęsny, D. Schwab, E. Nogoceke, R. Weikert, S. Fauser   +11 more
semanticscholar   +1 more source

Photoreceptor Inner Segment Morphology in Best Vitelliform Macular Dystrophy [PDF]

, 2016
PURPOSE To characterize outer retina structure in best vitelliform macular dystrophy (BVMD) and to determine the effect of macular lesions on overlying and adjacent photoreceptors.
Carroll, Joseph, Cooper, Robert F., Dubra, Alfredo, Higgins, Brian P., Johnson, Ryan D., Scoles, Drew, Stepien, Kimberly E., Sulai, Yusufu N.   +7 more
core   +2 more sources

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration

Journal of Neuroinflammation, 2020
Macular fibrosis causes irreparable vision loss in neovascular age-related macular degeneration (nAMD) even with anti-vascular endothelial growth factor (VEGF) therapy.
Karis Little, María Llorián-Salvador, Miao Tang, Xuan Du, Stephen Marry, Mei Chen, Heping Xu   +6 more
semanticscholar   +1 more source

Microperimetric evaluation in patients with adult-onset foveomacular vitelliform dystrophy [PDF]

, 2017
INTRODUCTION: To compare mean best-corrected visual acuity (BCVA), retinal sensitivity (RS), and bivariate contour ellipse area (BCEA) in patients with adult-onset foveomacular vitelliform dystrophy (AOFVD) and healthy subjects (HSs), reporting also ...
Cutini, Alessandro, Fragiotta, Serena, Grenga, Pier Luigi, Meduri, Alessandro, Vingolo, Enzo Maria   +4 more
core   +2 more sources

Refractive Index‐Corrected Light‐Sheet Microscopy for Macro‐View Cardiovascular Imaging

Advanced Science, EarlyView.
A refractive index‐corrected light‐sheet fluorescence microscopy system enables macro‐view cardiovascular imaging across organs, adapting to refractive index variations from different optical clearing protocols. By integrating axial sweeping, multi‐view imaging, and a sealed chamber, it extends the field of view, enhances isotropy, and improves safety.
Enbo Zhu, Yaran Zhang, Peng Zhao, Jae Min Cho, Zhaoqiang Wang, Yan‐Ruide Li, Jing Wang, Samuel Margolis, Shaolei Wang, Lili Yang, Alison Chu, Yuhua Zhang, Liang Gao, Tzung K. Hsiai   +13 more
wiley   +1 more source

Nutrients for Prevention of Macular Degeneration and Eye-Related Diseases

Antioxidants, 2019
The risk of macular degeneration can be reduced through the consumption of antioxidant-rich foods, supplements, and nutraceutical formulas. This review focuses on the antioxidants, vitamins, and minerals that have been reported for reducing the risk of ...
Hock Eng Khoo, Hui Suan Ng, Wai-Sum Yap, Henri Ji Hang Goh, Hip Seng Yim   +4 more
doaj   +1 more source