Results 41 to 50 of about 451,441 (295)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Prevalence of Mitral Annulus Disjunction and Mitral Valve Prolapse in Patients With Idiopathic Ventricular Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Idiopathic ventricular fibrillation (IVF) is diagnosed in patients with ventricular fibrillation of which the origin is not identified after extensive evaluations. Recent studies suggest an association between mitral annulus disjunction (MAD),
Sanne A. Groeneveld, Feddo P. Kirkels, Maarten J. Cramer, Reinder Evertz, Kristina H. Haugaa, Pieter G. Postema, Niek H. J. Prakken, Arco J. Teske, Arthur A. M. Wilde, Birgitta K. Velthuis, Robin Nijveldt, Rutger J. Hassink   +11 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

On Being Transminded: Disabling Achievement, Enabling Exchange

Disability Studies Quarterly, 2014
We write collaboratively, as a recent graduate and long-time faculty member of a small women’s liberal arts college, about the mental health costs of adhering to a feminist narrative of achievement that insists upon independence and resiliency.
Anne Dalke, Clare Mullaney
doaj   +1 more source

Inhibition of Drosophila Wg signaling involves competition between Mad and Armadillo/beta-catenin for dTcf binding. [PDF]

PLoS ONE, 2008
Precisely regulated signal transduction pathways are crucial for the regulation of developmental events and prevention of tumorigenesis. Both the Transforming Growth Factor beta (TGFbeta)/Bone morphogenetic protein (BMP) and Wnt/Wingless (Wg) pathways ...
Yi Arial Zeng, Maryam Rahnama, Simon Wang, Wendy Lee, Esther M Verheyen   +4 more
doaj   +1 more source

A survey and a molecular dynamics study on the (central) hydrophobic region of prion proteins

, 2014
Prion diseases are invariably fatal neurodegenerative diseases that affect humans and animals. Unlike most other amyloid forming neurodegenerative diseases, these can be highly infectious. Prion diseases occur in a variety of species.
Wang, Feng, Zhang, Jiapu
core   +1 more source

Permutation entropy and irreversibility in gait kinematic time series from patients with mild cognitive decline and early alzheimer’s dementia [PDF]

, 2019
Gait is a basic cognitive purposeful action that has been shown to be altered in late stages of neurodegenerative dementias. Nevertheless, alterations are less clear in mild forms of dementia, and the potential use of gait analysis as a biomarker of ...
Algarra Lucas, María del Carmen, Chicalna Actis, Guadalupe, Fernández Travieso, Jorge, Gómez Andrés, David, Martin Gonzalo, Juan Andrés, Miralles Martínez, Ambrosio A., Palmí Cartés, Itziar, Pulido Valdeolivas, Irene, Rausell, Estrella, Torrecillas Narváez, María Dolores, Wang, Ting, Wang, Yu, Zanin, Massimiliano   +12 more
core   +2 more sources

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Synthesis of a Novel Thermoresponsive S53P4 Bioactive Glass Extract–Poloxamer 407 Injectable Hydrogels: Assessment of Biocompatibility and Antimicrobial Properties

Advanced Engineering Materials, EarlyView.
This study investigates innovative thermoreversible hydrogels derived from S53P4 bioactive glass extracts to aid in the healing of infected diabetic foot wounds. These injectable gels, which gel at body temperature, release beneficial ions and remain stable over time.
Marian G. Vargas Guerrero, Adrian Stiller, Alex Nygård, Matej Krivulka, Lars Galema, Erwin Peters, Jimmy Lucchesi, Peter Uppstu, Leena Hupa, Jacobus J. C. Arts   +9 more
wiley   +1 more source

‘Are You a Radical Now?’ Reflecting on the Situation of Social Research(ers) in the Context of Service-User Activism in Mental Health

Journal of Social and Political Psychology, 2018
The relationship between activism and social research constitutes a longstanding source of debate. In the mental health and disability fields, this tension has specific connotations: User-survivor activism is premised on the priority of first-hand ...
Cristian R. Montenegro
doaj   +1 more source