Results 51 to 60 of about 8,672,142 (286)

Inhibition of Drosophila Wg signaling involves competition between Mad and Armadillo/beta-catenin for dTcf binding. [PDF]

open access: yesPLoS ONE, 2008
Precisely regulated signal transduction pathways are crucial for the regulation of developmental events and prevention of tumorigenesis. Both the Transforming Growth Factor beta (TGFbeta)/Bone morphogenetic protein (BMP) and Wnt/Wingless (Wg) pathways ...
Yi Arial Zeng   +4 more
doaj   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

open access: yesAdvanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo   +14 more
wiley   +1 more source

Into the Deep End: From Madness-as-Strategy to Madness-as-Right

open access: yesEuropean Journal of Analytic Philosophy
A central notion in Mad Pride activism is that “madness is a natural reaction” (Curtis et al. 2000, 22). In Madness: A Philosophical Exploration (2022), Justin Garson provides a compelling exploration and defence of this idea through the book’s central ...
Miguel Núñez de Prado-Gordillo
doaj   +1 more source

Donald Draper filosofo della nostalgia = Donald Draper as a Philosopher of Nostalgia

open access: yesH-ermes: Journal of Communication, 2016
Donald Draper as a Philosopher of Nostalgia. In contemporary media studies, the TV series Mad Men has been analyzed as an example of a nostalgic attitude towards a past era. In this paper, I will proceed the other way round.
Enrico Terrone
doaj   +1 more source

Real‐Time Stress Visualization of Hydrogels Enabled by Supramolecularly Switched Stretch‐Induced Phase Separation

open access: yesAdvanced Science, EarlyView.
Supramolecular hydrogels enable real‐time visualization of mechanical stress through supramolecular switching mechanotransduction. Adamantane‐modified cellulose functions as a responsive domain that undergoes an on–off transition between hydrated and dehydrated states via reversible β‐cyclodextrin–adamantane complexation and decomplexation.
Sooyeon Noh   +7 more
wiley   +1 more source

Impressum [PDF]

open access: yes, 2016
Impressum MAD ...
MAD, MAD
core  

I, 'Madman': An Autosomatography of Schizoaffective Disorder and Mad Subjectivity

open access: yesDisability Studies Quarterly, 2018
This paper is a learning of schizoaffective disorder through the lenses of slasher-cinema studies literature, subjectivity camera theory, and Mad Studies.
Greg Procknow
doaj   +1 more source

Brain‐Computer Interface Training Fosters Perceptual Skills to Detect Errors

open access: yesAdvanced Science, EarlyView.
Accurate perception of visuomotor errors underpins motor precision and learning, yet conventional behavioral training fails to improve sensitivity to subtle errors. Real‐time EEG‐based brain‐computer interface feedback targeting the error positivity component enhances perceptual learning of small errors.
Deland H. Liu   +4 more
wiley   +1 more source

New MAD publication: Medieval Animals on the Move Between Body and Mind (Palgrave, March 2021) [PDF]

open access: yes, 2021
Cover of the book: Medieval on the Move Medieval Animals on the Move: Between Body and Mind comprises a selection of peer-reviewed papers based on the 2017 conference of the Medieval Animal Database-Network (MAD), organized at the Department of ...
MAD
core  

The Paradox of Chivalric Madness: Ariosto’s and Cervantes’s Madness Representations’ Impact on Disability Representation

open access: yesHumanities
This study investigates the connection between madness and critiques of the chivalric romance genre in two late Renaissance works, Ludovico Ariosto’s Orlando Furioso and Miguel de Cervantes’s Don Quijote de la Mancha.
Nicholas L. Johnson
doaj   +1 more source

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