Results 91 to 100 of about 62,455 (285)

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Can Madness be Utopic? Analyzing Utopias through Madness as Political Praxis

Humana.Mente: Journal of Philosophical Studies
The paper contends that madness can be used as a way to engage with theories of utopia. The author draws upon their own autoethnographic experiences of madness and analyzes them through a Nietzschean perspective.
Riley Clare Valentine
doaj  

Cognitive Analysis of Madness in Qays ibn al-Moullawwāh’s Poem “When Will This Heart Find Rest”

Diglosia
This study analyzes the poetry of Qays ibn al-Mulawwaḥ to reconsider the notion of madness traditionally attributed to him. Rather than a psychological disorder or a reflection of biographical narratives, madness is shown to function as a cognitive ...
Layla Darwish
doaj   +1 more source

Survivor research in Canada: ‘talking’ recovery, resisting psychiatry, and reclaiming madness

, 2017
Beginning with discussion of what constitutes survivor research in Canada, this paper presents the findings of a critical discourse analysis of published accounts of survivor research over the last twenty-five years.
D. Landry
semanticscholar   +1 more source

Serial H&E Pathology Reveals Progression‐Associated Nuclear Size Drift as a Longitudinal Digital Readout of Bladder Cancer Evolution

Advanced Science, EarlyView.
Routine serial H&E specimens from bladder cancer are converted into paired T0/T1 digital pathology readouts of tumor evolution. Progression is associated with longitudinal nuclear drift, with nuclear size‐related changes most evident in the independent confirmation cohort, alongside a broader spatial burden of increased nuclear area and biological ...
Xing Liu, Zhen‐Duo Shi, Gong‐Cheng Wang, Jian‐Ming Wang, Ying Liu, Yi Gong, Xuan Lin, Di Wu, Shi‐Chao Zhuo, Han Han, Yi‐Bing Shi, Fan‐Lai Meng, Yu Zhang, Zhi‐Gang Jia, Cong‐Hui Han   +14 more
wiley   +1 more source

Ophelia, Beatrice-Joanna and Isabella: an Analysis of Madness and Lovesickness in Early Modern England

, 2023
reservedThe aim of this dissertation is to analyze how madness and lovesickness provided for the female protagonists of Hamlet and The Changeling an escape from the patriarchal society of early modern England.
FRADELLIN, SARA
core  

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55–ESCRT‐Associated Vesicular Damage Clearance

Advanced Science, EarlyView.
Oxaliplatin‐resistant colorectal cancer cells utilize a previously unappreciated PLK1‐CEP55‐ESCRT‐driven vesicular extrusion mechanism to clear L‐OHP‐induced cellular damage. The natural withanolide Tubocapsenolide A directly targets and inhibits PLK1 to disrupt this specific damage‐clearance machinery. This blockade induces severe nucleolar stress and
Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen   +15 more
wiley   +1 more source

Downsizing Electrophilic MAX‐Derived Helical Zipper Peptides to Covalently Bind and Degrade Oncogenic MYC

Angewandte Chemie, EarlyView.
Oncogenic MYC is a transcription factor that is difficult to inhibit. However, precise positioning of an acrylamide electrophile in MAX to covalently bond to the unique Cys438 in MYC, enabled shortening and optimizing of MAX‐derived, helix‐constrained peptides with high‐affinity and selectivity.
Aline Dantas de Araujo, Lei Luo, Mahan Azad, Miao Yu, Jody M. Mason, Junxian Lim, Timothy A. Hill, David P. Fairlie   +7 more
wiley   +2 more sources

Précis of Madness: A Philosophical Exploration

European Journal of Analytic Philosophy
The following is a short synopsis of the book Madness: A Philosophical Exploration. It provides an overview of the book’s core distinction between madness-as-dysfunction and madness-as-strategy, and enumerates four benefits of relying on this conceptual ...
Justin Garson
doaj  

Foucault and the Madness of Classifying Our Madness

Foucault Studies, 2016
This paper notes the re-ignited controversy surrounding the publication of a new edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V), suggesting that the early work of Michel Foucault can explain why the mere diagnosis of or ...
Drew Ninnis
doaj   +1 more source