Results 121 to 130 of about 203,465 (285)

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh   +5 more
wiley   +1 more source

Representations of madness in Indo-Caribbean literature [PDF]

open access: yes
This thesis presents a critical reading of selected Indo-Caribbean prose and poetry and explores their shared concern with issues of madness and insanity.
Gramaglia, Letizia
core  

“The purpose of activism is to educate”: Young people's climate activism as and for education in the youth strike movement in England

open access: yesBritish Educational Research Journal, EarlyView.
Abstract By skipping school for their cause, young climate strikers repeatedly demonstrated their priorities in 2019 and 2020. They regularly chose to sacrifice a day of their formal education in favour of collective action. This study asks what we can learn from the reflections of former youth strikers.
Loz J. Hennessy
wiley   +1 more source

Supernatural Agents of the Unconscious Mind: The Gothic Mode in Hamlet and Macbeth [PDF]

open access: yes, 2002
Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 dofinansowane zostało ze środków MNiSW w ramach działalności upowszechniającej ...
Wiśniewska, Dorota J.
core  

Trithio‐naphthalic anhydride‐based photosensitizer for photodynamic activity

open access: yesBulletin of the Korean Chemical Society, EarlyView.
A trithio‐naphthalic anhydride photosensitizer (NapS) is created by simple thionation, switching excited‐state pathways to deliver both type I and type II reactive oxygen species. NapS enables efficient photodynamic therapy under normoxia and hypoxia, achieving strong cancer cell killing with low dark toxicity.
Thanh Chung Pham   +6 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

open access: yesBMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou   +6 more
wiley   +1 more source

Why Are Consumers Ambivalent About AI‐Generated Images? The Moderating Role of Commercial Versus Noncommercial Content Type

open access: yesJournal of Consumer Behaviour, EarlyView.
ABSTRACT Grounded in ambivalence theories, this research examined factors shaping consumer ambivalence toward AI‐generated content and investigated differences between commercial and noncommercial contexts. As a preliminary study, sentiment analysis of Reddit data using a support vector machine (SVM) revealed that most consumer sentiment toward AI ...
Garim Lee   +3 more
wiley   +1 more source

Book review: madness, distress and the politics of disablement edited by Helen Spandler, Jill Anderson and Bob Sapey [PDF]

open access: yes, 2016
In Madness, Distress and the Politics of Disablement, editors Helen Spandler, Jill Anderson and Bob Sapey bring together contributors to explore the challenges of applying theories and policies of disability to understandings of madness and distress ...
Barham, Peter
core  

Madness, creativity and irrationality: the problem and its interpretation in the works of Michel Foucault

open access: yesRUDN journal of Sociology, 2014
The article examines the theme of madness and creativity in the works of one of the most famous scientists of the XX century - Michel Foucault. The author emphasizes the interpretation of the irrational side of the human consciousness, the relationship ...
E D Osipova
doaj  

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

open access: yesChronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy   +3 more
wiley   +1 more source

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