Results 61 to 70 of about 62,455 (285)

Restoring Madness to History in J.M. Coetzee’s In the Heart of the Country

open access: yesMediaTropes, 2015
This article interrogates the curious dismissal of madness from the critical landscape surrounding J. M. Coetzee’s In the Heart of the Country, and makes suggestions concerning how madness works in the novel and why—given certain critical and historical ...
William Collins
doaj  

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

open access: yesAdvanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang   +10 more
wiley   +1 more source

MADneSs: A Multi-Layer Anomaly Detection Framework for Complex Dynamic Systems

open access: yesIEEE Transactions on Dependable and Secure Computing, 2019
Anomaly detection can infer the presence of errors without observing the target services, but detecting variations in the observable parts of the system on which the services reside.
Tommaso Zoppi   +2 more
semanticscholar   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

open access: yesAdvanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Le fou social et le fou mental : amalgames théoriques, synthèses empiriques et rencontres institutionnelles

open access: yesSociologies, 2010
The purpose of this article is a) to better understand in general, throughout certain historic grounds and major institutional turns, for the most part in Quebec, the historically changing economy between two inseparable worlds, « mental madness » and ...
Marcelo Otero
doaj  

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

open access: yesAdvanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen   +7 more
wiley   +1 more source

Madness and Revenge: Gendered False Consciousness in the Golden Age Crime Novel

open access: yesForum, 2011
Elaine Showalter has objected to what she sees as a tendency in Cixous's writing to reflect on hysteria as a subversive and even empowering 'act' in the confrontation of patriarchy.
Samantha Walton
doaj   +3 more sources

Eschatological Madness in Michel Foucault’s analysis [PDF]

open access: yesEon
Michel Foucault does not propose a system of typologies for the phenomenon of madness. On the contrary, he acknowledges that this is not the intention of his analytical approach.
Marius CUCU, Oana LENȚA
doaj  

Rezension zur Ausstellung Madness & Modernity

open access: yes, 2010
Madness & Modernity. Kunst und Wahn in Wien um 1900. WienMusem Karlsplatz (21.01.2010 – 02.05.2010) Künstler spezialisieren sich auf „psychologische Portraits“ oder inszenieren sich als „wahnsinnig“, AnstaltspatientInnen betätigen sich künstlerisch,
madness
core  

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

open access: yesAdvanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias   +23 more
wiley   +1 more source

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