Results 131 to 140 of about 503,578 (359)

[Historic evocation]. [PDF]

open access: yesRev Fac Cien Med Univ Nac Cordoba, 2023
Acerbi Cremades N.
europepmc   +1 more source

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

open access: yesMolecular Oncology, EarlyView.
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová   +14 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

El papel de la aprehensión de los actos de habla en la comprensión de los enunciados.

open access: yesPragmalingüística, 2010
La teoría de los actos de habla afirma que para comprender un enunciado, es necesario reconocerlo como un acto ilocutivo. Sperber y Wilson (1986) toman una postura contraria al respecto, pero ninguna de las dos propuestas presenta suficiente evidencia ...
Hugo García Macías
doaj   +2 more sources

Datos acerca de varios maestros salmantinos [PDF]

open access: yes, 1924
Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Separata de: Homenaje a Menéndez Pidal. T.
Alonso Cortés, Narciso, 1875-1972
core   +1 more source

SensRORing cholesterol to drive protumoral myelopoiesis

open access: yesMolecular Oncology, EarlyView.
Bleve et al. uncover a cholesterol‐driven immune evasion pathway, where RORγ‐dependent myelopoiesis shapes tumor immunosuppression. Targeting RORγ and PCSK9 emerges as a strategy to boost cancer immunotherapy. Protumoral myelopoiesis is a determinant of immunoevasion and tumor spread in many malignancies.
Sara Gennari, Luigi Nezi, Teresa Manzo
wiley   +1 more source

Space, mass and ornament in the Gothic-Renaissance transition in Spain [PDF]

open access: yes, 2019
La introducción en España de las nuevas formas y sintaxis renacentistas a lo largo del siglo xvi no se produjo con un abandono radical e inmediato de los viejos usos góticos, de validez comprobada en trascendentales cuestiones del diseño ...
García Ortega, Antonio Jesús   +1 more
core  

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

open access: yesMolecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin   +10 more
wiley   +1 more source

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