Results 121 to 130 of about 6,213 (261)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

[Cuauhtémoc in the defense of Mexico-Tenochtitlan: The work of Luis Ortiz Monasterio in Oaxtepec]. [PDF]

Rev Med Inst Mex Seguro Soc
Rivas-Ruiz R.
europepmc   +1 more source

Decreased risk of COVID-19 pneumonia in children and adolescents during the Delta variant emergence. [PDF]

Public Health, 2022
Murillo-Zamora E, Trujillo X, Huerta M, Ríos-Silva M, Baltazar-Rodríguez LM, Guzmán-Esquivel J, Benites-Godínez V, Ortega-Ramírez AD, Mendoza-Cano O.   +8 more
europepmc   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Development and Testing of a Peer Recovery Support Services Intervention for Retention on Medications for Opioid Use Disorder. [PDF]

J Addict Med
Wenzel KR, Carrano J, Bormel A, Olaiya O, Pattanaik S, Fishman M.   +5 more
europepmc   +1 more source

COVID-19 vaccines provide better protection against related pneumonia than previous symptomatic infection. [PDF]

Int J Infect Dis, 2022
Murillo-Zamora E, Trujillo X, Huerta M, Ríos-Silva M, Guzmán-Esquivel J, Benites-Godínez V, Ochoa-Castro MR, Guzmán-Solórzano JA, Mendoza-Cano O.   +8 more
europepmc   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Primary health care policy investments in the Latin America context: Health systems experiences from Brazil, Chile, and Colombia. [PDF]

Health Policy Open
Massuda A, Fernandez M, Paschoalotto MAC, Kemper ES.   +3 more
europepmc   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Spanish to Mexican Sign Language glosses corpus for natural language processing tasks. [PDF]

Sci Data
Lara-Ortiz V, Fuentes-Aguilar RQ, Chairez I.   +2 more
europepmc   +1 more source