Results 101 to 110 of about 101,022 (282)
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Vida maestra de maestros : integración al aula/
, 2005 Serie documental producida en el año 2005. Este capítulo nos muestra el proyecto de "un espacio para vivir la democracia, la diversidad y la tolerancia" realizado en el colegio República Bolivariana de Venezuela IED en el cual se integra a los niños ...
core
Grit and working memory training outcomes for children with low working memory. [PDF]
Acta Paediatr, 2023 Spencer-Smith M +7 more
europepmc +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
RECIE Revista Electrónica Científica de Investigación Educativa, 2016 Esta ponencia es sobre una investigación realizada por parte de la Subdirección Académica y docentes de la Escuela Superior de Comercio y Administración, Unidad Santo Tomás (ESCASTO), del Instituto Politécnico Nacional (IPN).
Elia Olea Deserti +2 more
doaj
El maestro exterior y el Maestro interior en Del Maestro
ScientiAmericana Revista Multidisciplinaria, 2019 San Agustín en su obra Del Maestro sólo reconoce a Dios como Maestro y rechaza la idea de que el maestro humano enseñe. Ante esta situación, el interrogante que surge es ¿qué tarea atañe al hombre en su rol de educador si sólo Dios es Maestro? El presente trabajo, luego de un recorrido de los conceptos más relevantes de Del Maestro, propone un análisis
openaire +1 more source