Results 91 to 100 of about 6,213 (261)
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
RECIE Revista Electrónica Científica de Investigación Educativa, 2016 Esta ponencia es sobre una investigación realizada por parte de la Subdirección Académica y docentes de la Escuela Superior de Comercio y Administración, Unidad Santo Tomás (ESCASTO), del Instituto Politécnico Nacional (IPN).
Elia Olea Deserti +2 more
doaj
El maestro exterior y el Maestro interior en Del Maestro
ScientiAmericana Revista Multidisciplinaria, 2019 San Agustín en su obra Del Maestro sólo reconoce a Dios como Maestro y rechaza la idea de que el maestro humano enseñe. Ante esta situación, el interrogante que surge es ¿qué tarea atañe al hombre en su rol de educador si sólo Dios es Maestro? El presente trabajo, luego de un recorrido de los conceptos más relevantes de Del Maestro, propone un análisis
openaire +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Educación ambiental de maestros para maestros
, 2022 Este libro ha sido elaborado en el marco del proyecto de Transferencia del conocimiento proyecto (I+D+i): Teachers as Environmental Learning Hub:, financiado por la III Edición del Programa de Fomento de la Transferencia de Conocimiento de la Universidad Autónoma de Madrid (FUAM - Convenio: 0375/2022 Programa: 465059)
Pérez Martín, José Manuel +2 more
openaire +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Spiralling Pre-clerkship Concepts into the Clinical Phase: Augmenting Knowledge Transfer Using Innovative Technology-Enhanced Curriculum Activities. [PDF]
Med Sci Educ, 2021 Bracken K +5 more
europepmc +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Ptpn2: A Critical Regulator of Paneth Cell Homeostasis. [PDF]
Cell Mol Gastroenterol Hepatol, 2023 Theiss AL.
europepmc +1 more source