Results 101 to 110 of about 1,085,493 (335)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Magnesium enhances soil carbon sequestration by modulating carbon-cycling microorganisms under reduced fertilisation conditions

Scientia Horticulturae
Soil organic carbon (SOC) depletion remains a central challenge for tea plantations under intensive fertilisation. We evaluated three fertilisation strategies including farmer fertilisation (FF), optimised fertilisation (OF), and optimised fertilisation ...
Hao Ji, Hongyu Yang, Zetian Zhang, Hao Wu, Zhiyi Liu, Liangquan Wu, Shanghuan Li, Xuechun Li, Huihuang Wu, Chengcong Chen, Fuhan Lv, Linying Wang, Yirong Lai, Wei Lin, Lijin Guo   +14 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Superconducting magnesium diboride films with Tc \approx 24K grown by pulsed laser deposition with in-situ anneal

, 2001
Thin superconducting films of magnesium diboride (MgB2) with Tc \approx 24K were prepared on various oxide substrates by pulsed laser deposition (PLD) followed by an in-situ anneal.
B.C. Sales, Bud'ko, C. Cantoni, C. Rouleau, D.H. Lowndes, D.K. Christen, D.P. Norton, H.M. Christen, H.Y. Zhai, Kambara, M. Paranthaman, Nagamatsu, Yilmaz   +12 more
core   +1 more source

Magnesium [PDF]

Advances in Nutrition, 2016
Rebecca, Costello, Taylor C, Wallace, Andrea, Rosanoff   +2 more
openaire   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Machinability and surface integrity investigation during helical hole milling in AZ31 magnesium alloy

, 2022
Raviraja Adhikari, Gururaj Bolar, Ragavanantham Shanmugam, Uğur Köklü   +3 more
openalex   +1 more source

Magnesium [PDF]

Journal of Pain and Symptom Management, 2013
Vincent, Crosby, Ronald J, Elin, Robert, Twycross, Mary, Mihalyo, Andrew, Wilcock   +4 more
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source