Results 111 to 120 of about 1,085,493 (335)

Strength and High-Temperature Stability of Dispersion Strengthened Nickel-MgO Alloys [PDF]

open access: yes, 1961
Strength and high-temperature stability of dispersion strengthened nickel-magnesium oxide ...
Quatinetz, M.   +3 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Magnesium isotopes: a tool to understand self-enrichment in Globular Clusters

open access: yes, 2018
A critical issue in the asymptotic giant branch (AGB) self-enrichment scenario for the formation of multiple populations in Globular Clusters (GCs) is the inability to reproduce the magnesium isotopic ratios, despite the model in principle can account ...
D'Antona, Franca   +5 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Access to a Labile Monomeric Magnesium Radical by Ball‐Milling

open access: hybrid, 2022
Dawid Jędrzkiewicz   +6 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Influence of corrosive solutions on microhardness and chemistry of magnesium oxide /001/ surfaces [PDF]

open access: yes
X-ray photoelectron spectroscopy analyses and hardness experiments were conducted on cleaved magnesium oxide /001/ surfaces. The magnesium oxide bulk crystals were cleaved to specimen size along the /001/ surface, and indentations were made on the ...
Buckley, D. H.   +2 more
core   +1 more source

Apparatus for making a metal slurry product Patent [PDF]

open access: yes, 1960
Apparatus for producing hydrocarbon slurry containing small particles of magnesium for use as jet aircraft ...
Prok, G. M., Walsh, T. J., Witzke, W. R.
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

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