Results 111 to 120 of about 194,453 (318)

Optimal design of injection mold for plastic bonded magnet [PDF]

, 1991
The optimal design of an injection mold for producing a stronger multipole magnet is carried out using the finite element method and the direct search method. It is shown that the maximum flux density in the cavity obtained by the optimal design is about
Fujiwara, K., Kawashima, T., Nakata, Takayoshi, Takahashi, N.   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Ethical Values and Biological Diversity: A Preliminary Assessment Approach

Journal of Microbiology & Biology Education, 2014
There have been five major extinction events over geological time. However, the current rate of extinction or reduction of species and their habitats is directly related to anthropomorphic causes.
Joel I. Cohen
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Generation of On-line Optimal Current References for Multi-phase Permanent Magnet Machines with Open-circuited Phases [PDF]

, 2009
Acces éditeur : URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=5075280&isnumber=5075166This paper deals with the generation of optimal current references for Multi-phase Permanent Magnet Machines with open-circuited phases.
E. Semail, KESTELYN, Xavier, Y. Crevits, SEMAIL, Eric, CREVITS, Yvan, X. Kestelyn   +5 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Prototype REBCO Z1 and Z2 shim coils for ultra high-field

Scientific Reports, 2020
We present promising results of novel high-temperature superconducting (HTS) shim coil prototypes that circumvent the size and strength limitation of our earlier innovative HTS shim concept based on 46-mm wide REBCO tape.
Dongkeun Park, Jiho Lee, Juan Bascuñán, Zhuyong Li, Yukikazu Iwasa   +4 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

A general magnetic-energy-based torque estimator: validation via a permanent-magnet motor drive [PDF]

, 2008
This paper describes the use of the current–flux-linkage ($i{-}psi$ ) diagram to validate the performance of a general magnetic-energy-based torque estimator.
McGilp, M.I., Miller, T.J.E., Cossar, C., McGilp, M., Olaru, M., Popescu, M.   +5 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source