Results 91 to 100 of about 546,035 (307)

Machination and Manipulability System. A Dialogue between Martin Heidegger and Karel Kosík [PDF]

open access: yes, 2017
El concepto de “maquinación” (Machenschaft) ocupa un lugar central en la obra de Heidegger durante el período comprendido entre 1936 y 1940. En su análisis de la esencia de la época moderna, el filósofo checo de orientación marxista Karel Kosík se ...
Magnet Colomer, Jordi
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The Future of Official Language Minorities [PDF]

open access: yes, 1986
Quelle est la situation actuelle des langues minoritaires au Canada ? Tandis que les communautés de francophones hors Québec n'ont cessé de décroître depuis le siècle dernier, celle des anglophones du Québec avait su se maintenir jusqu'à récemment ...
Magnet, Joseph Eliot
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Prototype REBCO Z1 and Z2 shim coils for ultra high-field

open access: yesScientific Reports, 2020
We present promising results of novel high-temperature superconducting (HTS) shim coil prototypes that circumvent the size and strength limitation of our earlier innovative HTS shim concept based on 46-mm wide REBCO tape.
Dongkeun Park   +4 more
doaj   +1 more source

Electron spin resonance study of anisotropic interactions in a two-dimensional spin gap magnet PHCC

open access: yes, 2011
Fine details of the excitation spectrum of the two-dimensional spin-gap magnet PHCC are revealed by electron spin resonance investigations. The values of anisotropy parameters and the orientations of the anisotropy axes are determined by accurate ...
A. Abragam   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

DE LA ÉTICA DISCURSIVA A LA ÉTICA DEL RECONOCIMIENTO. UNA PANORÁMICA GENERAL AL MODELO ÉTICO DE HONNETH A TRAVÉS DE LA ETICIDAD HEGELIANA

open access: yesOxímora. Revista Internacional de Ética y Política, 2012
In the first section I deal with those limitations inherent in the “discourse ethics” which are object of a critical reception in Axel Honneth’s work, only from this basis one can see in perspective the influences of the hegelian  System of Ethical Life  
Jordi Magnet Colomer
doaj   +1 more source

Energy Deposition Studies for the Hi-Lumi LHC Inner Triplet Magnets

open access: yes, 2015
A detailed model of the High Luminosity LHC inner triplet region with new large-aperture Nb3Sn magnets, field maps, corrector packages, and segmented tungsten inner absorbers was built and implemented into the FLUKA and MARS15 codes.
Cerutti, F.   +6 more
core   +1 more source

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