Results 81 to 90 of about 194,453 (318)

Design and analysis of a new outer-rotor permanent-magnet flux-switching machine for electric vehicle propulsion

open access: yes, 2011
Purpose − The purpose of this paper is to propose a new outer-rotor permanent- magnet flux-switching machine for in-wheel electric vehicle propulsion.
Patrick Chi‐Kwong Luk   +7 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Research on the Airflow and Thermal Performance in a Large Forced Air-Cooled Permanent Magnet Synchronous Machine

open access: yesIEEE Access, 2019
In this paper, the airflow and temperature distribution characteristics of a 1.65MW permanent magnet synchronous machine (PMSM) adopting a totally enclosed self-circulation (TESC) axial ventilation system (AVS) are studied by numerical methods.
Wenming Tong, Shengnan Wu, Renyuan Tang
doaj   +1 more source

A novel permanent magnet flux switching machine with an outer-rotor configuration for in-wheel light traction applications [PDF]

open access: yes, 2012
This paper proposes a novel permanent magnet flux switching (PMFS) machine with an outer-rotor configuration for in-wheel light traction applications.
Shen, Jian-Xin   +4 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

MARCUSE, Herbert. (2019). Entre fenomenología y marxismo. Escritos filosóficos 1928-1933

open access: yesOxímora. Revista Internacional de Ética y Política, 2019
reseña de MARCUSE, Herbert. (2019). Entre fenomenología y marxismo. Escritos filosóficos 1928-1933. Compilación y traducción de José Manuel Romero Cuevas. Medellín: Editorial Universidad de Antioquia.
Jordi Magnet Colomer
doaj   +1 more source

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