Results 61 to 70 of about 114,108 (264)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Models for the magnetic field of M81

The Astrophysical Journal, 1993
We study several mean field dynamo models in disk geometry in an attempt to understand the origin of the nonaxisymmetric magnetic field present in M81. There appear to be three (at least) relevant mechanisms, which are not mutually exclusive. Because field growth times are not very short compared to galactic ages, a predominantly nonaxisymmetric seed ...
David Moss, Axel Brandenburg, Karl J. Donner, Magnus Thomasson   +3 more
openaire   +1 more source

Modeling of magnetic label field sensing by gmr structure

EPJ Web of Conferences, 2018
An analytical model is developed to calculate 3D spatial distribution of vector magnetic field H(r) around a reference magnetic label of an arbitrary shape.
Bukunov Kirill, Babaizev Georgy, Chechenin Nikolay   +2 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

International geomagnetic reference field: the fourteenth generation

Earth, Planets and Space
In November 2024, the International Association of Geomagnetism and Aeronomy (IAGA) Division V Working Group (V-MOD) adopted the fourteenth generation of the International Geomagnetic Reference Field (IGRF). This IGRF updates the previous generation with
C. D. Beggan, C. Kloss, P. Amblard, T. Amezza, H. Amit, J. Aubert, J. Baerenzung, J. Bregnhøj Lauridsen, W. Brown, S. Califf, S. A. Campuzano, L. Chauvet, A. Chulliat, R. Claveau, P. Coïsson, M. da Silva, C. Davies, R. Deborde, M. Dobrovolsky, M. Fillion, C. C. Finlay, I. Firsov, A. Fournier, L. Gailler, N. Gillet, N. Gomez Perez, A. Grayver, K. Gwirtz, M. Hamoudi, R. Holme, M. Holschneider, G. Hulot, T. Jager, Y. Jiang, M. Kada, M. Korte, R. Krasnoperov, W. Kuang, D. Kudin, J. M. Léger, A. Lemgharb, V. Lesur, P. Liu, P. W. Livermore, F. D. Madsen, M Mandea, M. Matsushima, J. Matzka, I. Michaelis, T. Minami, M. Nair, S. Nakano, J-F. Oehler, N. Olsen, F. J. Pavón-Carrasco, S. Presnyakov, B. Qian, X. Rang, H. F. Rogers, M. Rother, D. Rouxel, T. Sabaka, S. Sato, J. Saynisch-Wagner, M. Schanner, M. Serrano, N. Shakespeare-Rees, Y. Shi, A. Smith, A. Soloviev, F. Terra-Nova, E. Thebault, L. Tøffner-Clausen, H. Toh, J. Wang, I. Wardinski, C. Watson, K. Whaler, C. Xiong, Q. Yan, Y. Yang, H. Yao, Z. Zeren, K. Zhang, B. Zhou   +84 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Progress and challenges in modeling global lithospheric magnetic anomalies

地球与行星物理论评
Over the past 50 years, extensive airborne and oceanic magnetic survey data collection efforts have resulted in the almost complete coverage of near-surface magnetic survey data worldwide.
Yao Luo, Jingmin Li, Jinxin Zheng, Xue Yang, Hang Yin, Wenzhi Zhang, Qingkui Meng, Bing Li, Linfei Wang   +8 more
doaj   +1 more source