Results 41 to 50 of about 106,806 (266)

Analysis of Spatiotemporal Characteristics for Underwater Target’s Comprehensive Magnetic Field

open access: yes水下无人系统学报
The accurate modeling of the radiated magnetic field of underwater targets is of great significance to the development of magnetic detection technology.
Xinyu DONG, Honglei WANG, Yixin YANG
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Research on Finite Permeability Semi-Analytical Harmonic Modeling Method for Maglev Planar Motors

open access: yesMagnetism
This study proposes a semi-analytic harmonic modeling method that significantly improves the accuracy and efficiency of complex magnetic field modeling by integrating numerical and analytical approaches.
Yang Zhang, Chunguang Fan, Chenglong Yu
doaj   +1 more source

A Proper Use of the Adjacent Land‐Based Observatory Magnetic Field Data to Account for the Geomagnetic Disturbances During Offshore Directional Drilling

open access: yesSpace Weather, 2022
Directional drilling in the oil fields relies particularly on the “on‐fly” measurements of the natural magnetic field (measurements while drilling; MWD); the MWD are eventually used to construct the well path.
Mikhail Kruglyakov   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

The Magnetic Field from Cylindrical Arc Coils and Magnets: A Compendium with New Analytic Solutions for Radial Magnetization and Azimuthal Current

open access: yesAdvanced Physics Research
This study provides analytic solutions for the magnetic field of coils and magnets that have a non‐axisymmetric cylindrical geometry with a rectangular cross‐section. New analytic solutions are provided for radially magnetized permanent magnet arcs, thin
Matthew Forbes   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

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