Results 51 to 60 of about 788,468 (298)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Electrical Conductivity of Field-Structured Emulsions

Fluids, 2020
The structure formation influence on various macroscopic properties of fluid–fluid disperse systems is poorly investigated. The present work deals with the experimental study of the charge transfer in emulsions whose dispersed phase droplets are arranged
Arthur R. Zakinyan, Ludmila M. Kulgina, Anastasia A. Zakinyan, Sergey D. Turkin   +3 more
doaj   +1 more source

Nonlinearity in a dynamo [PDF]

, 2009
Using a rotating flat layer heated from below as an example, we consider effects which lead to stabilizing an exponentially growing magnetic field in magnetostrophic convection in transition from the kinematic dynamo to the full non-linear dynamo.
Cattaneo F, Chandrasekhar S, Hughes D, Kazantsev AP, Kleeorin N, M. Reshetnyak, Moffatt HK, P. Hejda, Rose HA, Zeldovich YaB   +9 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Collisional transport across the magnetic field in drift-fluid models [PDF]

, 2016
Drift ordered fluid models are widely applied in studies of low-frequency turbulence in the edge and scrape-off layer regions of magnetically confined plasmas.
A. H. Nielsen, Braginskii S. I., Helander P., J. Juul Rasmussen, J. Madsen, V. Naulin   +5 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Experimental Study on Thermal Conductivity of Hybrid Magnetic Fluids Under External Magnetic Field

Magnetochemistry
In the paper, a hybrid magnetic fluid is prepared by adding carbon nanotubes to pure ferrofluid to improve its thermal conductivity. Furthermore, an electromagnet is used as magnetic source equipment, and the magnetic field strength in the air gap of the
Licong Jin, Jixian Yang, Qian Li, Xin Tian, Decai Li   +4 more
doaj   +1 more source

Rotation of Magnetization Derived from Brownian Relaxation in Magnetic Fluids of Different Viscosity Evaluated by Dynamic Hysteresis Measurements over a Wide Frequency Range

Nanomaterials, 2016
The dependence of magnetic relaxation on particle parameters, such as the size and anisotropy, has been conventionally discussed. In addition, the influences of external conditions, such as the intensity and frequency of the applied field, the ...
Satoshi Ota, Ryoichi Kitaguchi, Ryoji Takeda, Tsutomu Yamada, Yasushi Takemura   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

On the solution of the steady‐state diffusion problem for ferromagnetic particles in a magnetic fluid

Mathematical Modelling and Analysis, 2008
A mathematical model for the diffusion process of ferromagnetic particles in a magnetic fluid is described. The unique solvability of the steady‐state particle concentration problem is investigated and an analytical expression for its solution is found ...
Viktor Polevikov, Lutz Tobiska
doaj   +1 more source