Results 61 to 70 of about 1,701,138 (265)

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Monocore vs multicore magnetic iron oxide nanoparticles: uptake by glioblastoma cells and efficiency for magnetic hyperthermia

, 2017
International audiencePEGylated magnetic iron oxide nanoparticles (IONPs) were synthesised with the aim to provide proof of concept results of remote cancer cell killing by magnetic fluid hyperthermia.
Gauvin Hemery, Garanger, Elisabeth, Sabrina Lacomme, Couillaud, Franck, Franck Couillaud, Sandre, Olivier, Coralie Genevois, Gontier, Etienne, Genevois, Coralie, Olivier Sandre, Lecommandoux, Sébastien, Lacomme, Sabrina, Elisabeth Garanger, Etienne Gontier, Sébastien Lecommandoux, Emmanuel Ibarboure, Ibarboure, Emmanuel, Hemery, Gauvin   +17 more
core   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Drug Delivery and Magnetic Hyperthermia Based on Surface Engineering of Magnetic Nanoparticles

, 2021
Magnetic nanoparticles (MNP) have highlighted its relevance in biomedical applications as drug delivery and magnetic hyperthermia devices due to their high surface area, low toxicity, and biocompatibility, as well as intrinsic magnetic properties.
Bruno E. Amantéa, Pinto, Gabriel C. [UNESP], Guilherme N. Lucena, Caio C. dos Santos, Miguel Jafelicci, dos Santos, Caio C. [UNESP], Rodolfo D. Piazza, Gabriel C. Pinto, Lucena, Guilherme N. [UNESP], Amantéa, Bruno E. [UNESP], Piazza, Rodolfo D. [UNESP], Rodrigo Fernando C. Marques, Jafelicci, Miguel [UNESP], Marques, Rodrigo Fernando C. [UNESP]   +13 more
core   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

In silico experiments as a tool to reduce preclinical tests of magnetic hyperthermia [PDF]

, 2021
In silico models can be useful tools to guide preclinical tests of magnetic hyperthermia, which employs Magnetic Nanoparticles (MNPs) excited by AC magnetic fields, as heat mediators for cancer cure.
Ferrero, Riccardo, Marta Vicentini, Marta Vassallo, Vicentini, Marta, Alessandra Manzin, Vassallo, Marta, Manzin, Alessandra, Riccardo Ferrero   +7 more
core   +1 more source

Dependence of Ultrasonic and Magnetic Hyperthermia on the Concentration of Magnetic Nanoparticles [PDF]

Acta Physica Polonica A, 2018
Hyperthermia treatment is the heating of tumor tissue up to temperatures between 41 ºC and 45 ºC, which trigger several physiological reactions in the body. Hyperthermia within tissue can be applied through various mechanisms. One of them is magnetic hyperthermia which uses superparamagnetic iron oxide nanoparticles (SPIONs) heated by an externally ...
Kaczmarek, K., Hornowski, T., Bielas, R., Żak, D., Timko, M., Józefczak, A.   +5 more
openaire   +2 more sources

Field‐Driven Active Colloids as Distributed Micromachines: Bridging Physics, Control, and Function Across Length Scales

Advanced Science, EarlyView.
Field‐driven active colloids are framed as distributed micromachines in which externally supplied power, sensing, and control regulate task‐relevant states. By closing the loop between particle behavior, imaging, computation, and electric or magnetic actuation, these systems can progress from programmable motion toward adaptive functional outcomes ...
Ruchi Patel, Bhuvnesh Bharti
wiley   +1 more source

Synthesis of Zinc Ferrites in RF Thermal Plasma Reactor [PDF]

, 2007
Formation of nanosized zinc ferrite spinels was studied from iron- and zinc oxide powders and corresponding nitrate solutions, respectively in a radiofrequency thermal plasma reactor.
Mészáros, I., Mohai, Ilona, Gubicza, Jenő, Gál, L., Szépvölgyi, János   +4 more
core   +1 more source

Optimizing magnetic hyperthermia for melanoma: the role of nanoparticle uptake inhibition

Nano Express
Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used in magnetic hyperthermia, where their therapeutic efficacy depends on efficient heat generation.
Beatriz T Simões, Catarina Chaparro, Tânia Vieira, Manuel A Valente, Marco C V Cavaco, Vera Neves, Jorge C Silva, João Paulo Borges, Filipe V Almeida, Paula Soares   +9 more
doaj   +1 more source