Results 41 to 50 of about 882,368 (266)

Multiparametric mri-based radiomics nomogram for predicting lymph-vascular space invasion in cervical cancer

BMC Medical Imaging
Purpose To develop and validate a multiparametric magnetic resonance imaging (mpMRI)-based radiomics model for predicting lymph-vascular space invasion (LVSI) of cervical cancer (CC). Methods The data of 177 CC patients were retrospectively collected and
Feng-Hai Liu, Xin-Ru Zhao, Xiao-Ling Zhang, Meng Zhao, Shan Lu   +4 more
doaj   +1 more source

Static and temporal dynamic changes of intrinsic brain activity in early-onset and adult-onset schizophrenia: a fMRI study of interaction effects

Frontiers in Neurology
BackgroundSchizophrenia is characterized by altered static and dynamic spontaneous brain activity. However, the conclusions regarding this are inconsistent.
Jingli Chen, Jingli Chen, Jingli Chen, Yarui Wei, Yarui Wei, Kangkang Xue, Kangkang Xue, Xinyu Gao, Xinyu Gao, Mengzhe Zhang, Mengzhe Zhang, Shaoqiang Han, Shaoqiang Han, Baohong Wen, Baohong Wen, Guangyu Wu, Jingliang Cheng, Jingliang Cheng   +17 more
doaj   +1 more source

Brain network construction and analysis for patients with mild cognitive impairment and Alzheimer's disease based on a highly‐available nodes approach

Brain and Behavior, 2021
Introduction Using brain network and graph theory methods to analyze the Alzheimer's disease (AD) and mild cognitive impairment (MCI) abnormal brain function is more and more popular. Plenty of potential methods have been proposed, but the representative
Xiaopan Zhang, Junhong Liu, Yuan Chen, Yanan Jin, Jingliang Cheng, for the Alzheimer’s Disease Neuroimaging Initiative   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Altered Resting-State Functional Connectivity in Internet Gaming Disorder: Convergent Evidence and Independent Validation

Addictive Behaviors Reports
Background: Internet gaming disorder (IGD) has attracted increasing attention worldwide. However, findings from resting-state functional connectivity (RSFC) studies have remained inconsistent, making it difficult to identify robust and reproducible ...
Jiawen Tian, Hui Zhang, Xinyu Wang, Hongyu Zhang, Longyao Ma, Bohui Mei, Mengzhe Zhang, Yan Lang, Yarui Wei, Shaoqiang Han, QingQing Lv, Yong Zhang   +11 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Altered functional connectivity within the primary visual networks and neurotransmitter activity in male smokers: A group ICA study

Brain Research Bulletin
Smoking puts patients at high risk for cognitive and psychiatric disorders. The aim of this study was to explore the effects of nicotine use on primary visual network (PVN) and its association with neurotransmitters.
Jieping Sun, Jinghan Dang, Mengzhe zhang, Xiaoyu Niu, Qiuying Tao, Yimeng Kang, Longyao Ma, Bohui Mei, Yarui Wei, Weijian Wang, Shaoqiang Han, Jingliang Cheng, Yong Zhang   +12 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Diagnostic utility of cardiac magnetic resonance-derived myocardial strain and fractal analysis in differentiating left ventricular noncompaction from dilated cardiomyopathy

BMC Medical Imaging
Objective This study aimed to evaluate the diagnostic value of combining cardiac magnetic resonance (CMR) myocardial strain analysis with fractal analysis in differentiating left ventricular noncompaction (LVNC) from dilated cardiomyopathy (DCM). Methods
Yanan Jin, Yong Zhang, Jingliang Cheng, Xiaoning Shao, Yan Zhang   +4 more
doaj   +1 more source