Results 71 to 80 of about 1,628,480 (298)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Resting-state functional connectivity alterations in intermet gaming disorder: A fMRI study combining voxel-based morphometry meta-analysis

Brain Research Bulletin
Background: Internet gaming disorder (IGD) is a behavioral addiction, as revealed by previous neuroimaging studies on gray matter volume alterations and functional connectivity abnormalities that patients with internet gaming disorder have.
Xinyu Wang, Wenjing Li, Yimeng Kang, Longyao Ma, Bohui Mei, Hui Zhang, Jiawen Tian, Qingqing Lv, Shaoqiang Han, Yong Zhang, Weijian Wang   +10 more
doaj   +1 more source

Stabilization of parameter estimates from multiexponential decay through extension into higher dimensions

Scientific Reports, 2022
Analysis of multiexponential decay has remained a topic of active research for over 200 years. This attests to the widespread importance of this problem and to the profound difficulties in characterizing the underlying monoexponential decays.
Chuan Bi, Kenneth Fishbein, Mustapha Bouhrara, Richard G. Spencer   +3 more
doaj   +1 more source

Noninvasive monitoring of radiotherapy-induced microvascular changes using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in a colorectal tumor model [PDF]

, 2006
To examine dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with a macromolecular contrast agent (P792) to visualize effects of radiotherapy (RT) on microvascular leakage in a colorectal cancer model.Journal Articleinfo:eu-repo/semantics ...
Backes, Walter, Boterberg, Tom, BOUCKENOOGHE, ISABEL, Ceelen, Wim, DE VISSCHERE, MARIEKE, Demetter, Pieter, Pattyn, Piet, Peeters, Marc, Smeets, Peter, Van Damme, Nancy   +9 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Autism and Research Using Magnetic Resonance Imaging [PDF]

, 2017
This qualitative study explored the experience of participating in a research study using magnetic resonance imaging (MRI) for children with autism spectrum disorder (ASD), typically developing (TYP) children, and their parent.
Chapman, Ehlers, Giarelli, Gray, Holloway, Ismail, Johnson, Johnson, Kaufman, Kohler Riessman, Koller, Lord, Munn, Nordahl, Nordahl, Salowitz, Schlund, Simonoff, Thompson, Vandermeer, Volkmar, Wang   +21 more
core   +2 more sources

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A Pneumatically Actuated Manipulandum for Neuromotor Control Research [PDF]

, 2002
Functional magnetic resonance imaging (fMRI) techniques have great potential for identifying which neural structures are involved in the control of goal-directed reaching movements.
Ropella, Kristina M., Scheidt, Robert A., Suminski, Aaron J   +2 more
core   +1 more source