Results 21 to 30 of about 519,038 (293)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Multivariate metal-organic frameworks enable chemical shift-encoded MRI with femtomolar sensitivity for biological systems

Nature Communications
Fluorescent molecules with specific target moieties are essential for histopathological analysis, but their limited tissue penetration depth makes in vivo, in situ color encoding analysis challenging.
Qingbin Zeng, Quer Yue, Ming Zhang, Rui Zhou, Zhen Wang, Zhongyu Xiao, Yaping Yuan, Xiuchao Zhao, Weiping Jiang, Lei Zhang, Yuqi Yang, Minghui Yang, Haidong Li, Louis-S. Bouchard, Qianni Guo, Xin Zhou   +15 more
doaj   +1 more source

Development and Applications of HDX-NMR and HDX-MS in Protein Structure and Dynamics Research

Chinese Journal of Magnetic Resonance
Hydrogen-deuterium exchange nuclear magnetic resonance (HDX-NMR) and hydrogen-deuterium exchange mass spectrometry (HDX-MS) are key techniques for studying protein structure and dynamics, and have been widely applied to analyzing protein conformational ...
ZHANG Yuanyuan, WANG Pengcheng, LI Tao, HU Rui, YANG Yunhuang, LIU Maili   +5 more
doaj   +1 more source

A Review of Diffusion Magnetic Resonance Imaging in Characterization of Breast Cancers

Frontiers in Biomedical Technologies, 2022
Diffusion Magnetic Resonance Imaging (dMRI) has widely been used as a part of breast MRI protocols throughout the world, providing valuable information about breast tissue structures.
Mohammad Reza Alviri, Anahita Fathi Kazerooni, Soheila Koopaee, Hamidreza Saligheh Rad, Masoumeh Gity   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Unveiling the thermodynamic-kinetic trade-off effect on acid sites in zeolite-catalyzed alcohol dehydration

Nature Communications
Understanding the distinct roles of Brønsted and Lewis acid sites remains a great challenge in designing zeolite catalysts, as their coexistence often obscures mechanistic understanding.
Min Hu, Yueying Chu, Chao Wang, Wenjin Cai, Qiang Wang, Jun Xu, Feng Deng   +6 more
doaj   +1 more source

Differential Diagnosis Among Alzheimer's Disease, Mild Cognitive Impairment, and Normal Subjects Using Resting-State fMRI Data Extracted from Multi Subject Dictionary Learning Atlas

Frontiers in Biomedical Technologies, 2022
Purpose: A powerful imaging method for evaluating brain patches is resting-state functional magnetic resonance imaging, in which the subject is at rest. Artificial neural networks are one of the several Alzheimer's disease analysis and diagnosis methods
Farzad Alizadeh, Hassan Homayoun, Amir hossein Batouli, Maryam Noroozian, Forough Sodaie, Hanieh Mobarak Salary, Anahita Fathi Kazerooni, Hamidreza Saligheh Rad   +7 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Programmable macrophage-polarizing nanoparticles for MRI-guided early detection and treatment of pulmonary metastases

Journal of Nanobiotechnology
Metastatic lung cancer remains a leading cause of cancer-related mortality worldwide, underscoring the urgent need for early detection and intervention strategies.
Meiju Sui, Kairu Xie, Yingying Luo, Haiqiang Wang, Hao Sheng, Sen Yue, Xiaoxun Liu, Sha Li, Jung Soo Suk, Shizhen Chen, Daiqin Chen, Xin Zhou   +11 more
doaj   +1 more source