Results 31 to 40 of about 258,012 (314)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Effects of Seizure-inducing Doses Nicotine on Hippocampal Structure in Adolescent Female Rats

Chinese Journal of Magnetic Resonance
In recent years, there have been frequent cases of seizures among adolescents after using e-cigarettes, which has aroused deep concern about the potential health risks of excessive nicotine intake.
CHEN Xi, LIU Sijie, CAI Yue, CHENG Linlin, WANG Xuxia, KANG Yan, LIN Fuchun, LEI Hao   +7 more
doaj   +1 more source

A Review of Diffusion Magnetic Resonance Imaging in Characterization of Breast Cancers

Frontiers in Biomedical Technologies, 2022
Diffusion Magnetic Resonance Imaging (dMRI) has widely been used as a part of breast MRI protocols throughout the world, providing valuable information about breast tissue structures.
Mohammad Reza Alviri, Anahita Fathi Kazerooni, Soheila Koopaee, Hamidreza Saligheh Rad, Masoumeh Gity   +4 more
doaj   +1 more source

Magnetic resonance spectroscopy in the evaluation of treatment efficacy in unipolar major depressive disorder: a review of the literature [PDF]

, 2012
More and more neuroimaging studies are using in vivo proton magnetic resonance spectroscopy (1H-MRS) to explore correlates of response to therapy in major depressive disorder (MDD). Their aim is to further understanding of the effects of neurotransmitter
A. Pichiecchio, F. Barale, M. Pasin, Biondi, Massimo, Palesi, Fulvia, Caverzasi, Edoardo, Pasquini, Massimo, G. Castellazzi, Bastianello, Stefano, A. Calligaro, Barale, Francesco, E. Caverzasi, Pichiecchio, Anna, Pasin, Marino, Castellazzi, Gloria, Calligaro, Alessandro, F. Palesi, Poloni, Guy, G. U. Poloni   +18 more
core  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

NMR-guided rational exploration of co-factors in boosting the Pfu DNA polymerase

Magnetic Resonance Letters
With rapid developments of emerging technologies like synthetic biology, the demand for DNA polymerases with superior activities including higher thermostability and processivity has increased significantly. Thus, rational optimization of the performance
Yihao Chen, Mingjun Zhu, Ruishen Ding, Xiaoling Zhao, Zhiqing Tao, Xu Zhang, Maili Liu, Lichun He   +7 more
doaj   +1 more source

Use of Nuclear Magnetic Resonance Imaging Angiography to Follow-Up Arterial Remodeling in an Animal Model [PDF]

, 1998
Appropriately sized arteries in small animals may be possible models for studying the remodeling process as occurs after arterial balloon injury in humans. Magnetic resonance imaging (MRI) is able to noninvasively image tissue in vivo.
Schwaiger, Markus, Huehns, Tanya Y., Höfling, Berthold, Nekolla, Stephan, Nikol, Sigrid, Schirmer, Johannes, Esin, Serap   +6 more
core   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Structural insights into a highly flexible zinc finger module unravel INSM1 function in transcription regulation

Nature Communications
Orderly development of neuroendocrine and nervous system of mammals requires INSM1, a key regulator for cell differentiation. Ectopic expression of INSM1 is closely correlated with human neuroendocrine tumorigenesis, which makes INSM1 a reliable ...
Heng Zhou, Xiaoling He, Yue Xiong, Yixuan Gong, Yuanyuan Zhang, Shuangli Li, Rui Hu, Ying Li, Xu Zhang, Xin Zhou, Jiang Zhu, Yunhuang Yang, Maili Liu   +12 more
doaj   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source